Xu Yang, Zhao Wenli, Li Te, Bu Huaien, Zhao Zhimei, Zhao Ye, Song Shilin
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.
Department of Gynecology and Obstetrics, Nankai Hospital, Tianjin Academy of Integrative Medicine, Tianjin, 300100, China.
BMC Complement Altern Med. 2017 Aug 31;17(1):436. doi: 10.1186/s12906-017-1924-8.
Primary dysmenorrhoea (PD), defined as painful menses in women with normal pelvic anatomy, is one of the most common gynaecological syndromes. Acupoint-stimulation could potentially be an effective intervention for PD. Our aim was to determine the effectiveness of acupoint-stimulation compared with Non-Steroidal Anti-Inflammatory Drugs (NASIDs) in the treatment of PD.
Six databases were searched to December 2014. Sixteen studies involving 1679 PD patients were included. We included randomized controlled trials that compared acupoint-stimulation with NASIDs for the treatment of PD. The main outcomes assessed were clinical effectiveness rate, symptom score, visual analogue score, variation in peripheral blood prostaglandin F2α (PGF2α) and side effects. All analyses were performed using Comprehensive Meta-Analysis statistical software.
(1) The total efficacy was better than control group: odds ratio = 5.57; 95% confidence interval (95% CI) = 3.96, 7.83; P < 0.00001; (2) The effect of intervention was positive in relieving the severity of PD symptoms: mean difference (MD) = 2.99; 95%CI = 2.49, 3.49; P < 0.00001; (3) No statistical difference existed between two groups in terms of a reduction in the VAS: MD = 1.24; 95%CI = -3.37, 5.85; P = 0.60; (4) The effect of intervention on the variation in peripheral blood PGF2α between two groups was positive: MD = 7.55; 95%CI = 4.29,10.82; P < 0.00001; (5) The side effects of control groups was more than the acupoint-stimulation group: OR = 0.03; 95%CI =0.00,0.22; P = 0.0005.
According to this article, acupoint-stimulation can relieve pain effectively in the treatment of PD and offers advantages in increasing the overall effectiveness.
原发性痛经（PD）定义为盆腔解剖结构正常的女性出现的痛经，是最常见的妇科综合征之一。穴位刺激可能是治疗PD的一种有效干预措施。我们的目的是确定穴位刺激与非甾体抗炎药（NASIDs）相比治疗PD的有效性。
检索至2014年12月的六个数据库。纳入了16项涉及1679例PD患者的研究。我们纳入了比较穴位刺激与NASIDs治疗PD的随机对照试验。评估的主要结局包括临床有效率、症状评分、视觉模拟评分、外周血前列腺素F2α（PGF2α）的变化及副作用。所有分析均使用综合荟萃分析统计软件进行。
（1）总疗效优于对照组：比值比=5.57；95%置信区间（95%CI）=3.96，7.83；P<0.00001；（2）干预对缓解PD症状的严重程度有积极作用：平均差值（MD）=2.99；95%CI=2.49，3.49；P<0.00001；（3）两组在视觉模拟评分降低方面无统计学差异：MD=1.24；95%CI=-3.37，5.85；P=0.60；（4）干预对两组外周血PGF2α变化的影响是积极的：MD=7.55；95%CI=4.29，10.82；P<0.00001；（5）对照组的副作用多于穴位刺激组：比值比=0.03；95%CI=0.00，0.22；P=0.0005。
根据本文，穴位刺激在治疗PD时能有效缓解疼痛，并在提高总体疗效方面具有优势。
