Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan , Ann Arbor, Michigan.
Department of Microbiology and Immunology, University of Michigan , Ann Arbor, Michigan.
Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L6-L16. doi: 10.1152/ajplung.00344.2017. Epub 2017 Aug 31.
The IL-17 family of cytokines has emerged over the last two decades as a pleiotropic group of molecules that function in a wide variety of both beneficial and detrimental (pathological) processes, mainly in mucosal barrier tissue. The beneficial effects of IL-17 expression are especially important in the lung, where exposure to foreign agents is abundant. IL-17A plays an important role in protection from both extracellular bacteria and fungi, as well as viruses that infect cells of the mucosal tracts. IL-17 coregulated cytokines, such as IL-22, are involved in maintaining epithelial cell homeostasis and participate in epithelial cell repair/regeneration following inflammatory insults. Thus, the IL-17/IL-22 axis is important in both responding to, and recovering from, pathogens. However, aberrant expression or overexpression of IL-17 cytokines contributes to a number of pathological outcomes, including asthma, pneumonitis, and generation or exacerbation of pulmonary fibrosis. This review covers the good, bad, and ugly aspects of IL-17 in the lung.
在过去的二十年中，IL-17 细胞因子家族已成为一组多功能分子，在多种有益（生理性）和有害（病理性）过程中发挥作用，主要在黏膜屏障组织中发挥作用。IL-17 表达的有益作用在肺部尤其重要，因为肺部暴露于大量的外来物质。IL-17A 在抵御胞外细菌和真菌以及感染黏膜细胞的病毒方面发挥着重要作用。IL-17 共同调节的细胞因子，如 IL-22，参与维持上皮细胞的稳态，并参与炎症损伤后的上皮细胞修复/再生。因此，IL-17/IL-22 轴在应对和从病原体中恢复方面都很重要。然而，IL-17 细胞因子的异常表达或过度表达导致许多病理结果，包括哮喘、肺炎和肺纤维化的发生或恶化。这篇综述涵盖了 IL-17 在肺部的有益、有害和不良方面。
