St George-Hyslop P, Polinsky R, Haines J, Nee L, Tanzi R, Conneally P, Growdon J, Myers R, Pollen D, Drachman D
Neurogenetics Laboratory, Massachusetts General Hospital, Boston.
J Neural Transm Suppl. 1987;24:13-21.
The application of molecular genetic techniques to the study of autosomal dominantly inherited Familial Alzheimer's Disease may provide a means to determine the chromosomal location of the defective gene causing this form of Alzheimer's disease. Knowledge of the chromosomal location of the defective gene will provide a basis for isolating and characterizing this gene. Preliminary investigations indicate that several candidate genes can be excluded as the site of the defect. Current data also indicate that the defective gene does not reside close to random DNA markers on the distal portion of chromosome 21. Additional DNA markers on the proximal portion of chromosome 21 long arm are currently being investigated.
将分子遗传学技术应用于常染色体显性遗传的家族性阿尔茨海默病的研究，可能为确定导致这种形式的阿尔茨海默病的缺陷基因的染色体定位提供一种方法。了解缺陷基因的染色体定位将为分离和鉴定该基因提供基础。初步调查表明，几个候选基因可以被排除在缺陷位点之外。目前的数据还表明，缺陷基因并不位于21号染色体远端的随机DNA标记附近。目前正在研究21号染色体长臂近端的其他DNA标记。
