College of Chemistry and Environmental Science, and ‡School of Pharmaceutical Science, Hebei University , Baoding, Hebei Province 071002, People's Republic of China.
ACS Appl Mater Interfaces. 2017 Sep 20;9(37):31626-31633. doi: 10.1021/acsami.7b10867. Epub 2017 Sep 12.
A novel chemical hydrogel was facilely achieved by coupling 1,4-phenylenebisdiboronic acid modified halloysite nanotubes (HNTs-BO) with compressible starch. The modified halloysite nanotubes (HNTs) and prepared hydrogel were characterized by solid-state nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscope (TEM). The linkage of B-C in the hydrogel can be degraded into B-OH and C-OH units in the presence of HO and result in the degradation of the chemical hydrogel. Pentoxifylline was loaded into the lumen of the HNTs-BO, and then gave the pentoxifylline-loaded hydrogel. The drug release profile shows that it was no more than 7% dissolved when using phosphate buffer solution (PBS) as the release medium. Notably, a complete release (near 90%) can be achieved with the addition of HO ([HO] = 1 × 10 M), suggesting a high HO responsiveness of the as-formed hydrogel. The drug release results also show that the "initial burst release" can be effectively suppressed by loading pentoxifylline inside the lumen of the HNTs rather than embedding the drug in the hydrogel network. The drug-loaded hydrogel with HO-responsive release behavior may open up a broader application in the field of biomedicine.
一种新型的化学水凝胶通过将 1,4-苯二硼酸修饰的埃洛石纳米管（HNTs-BO）与可压缩淀粉偶联而轻易实现。修饰后的埃洛石纳米管（HNTs）和制备的水凝胶通过固态核磁共振（NMR）、傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）进行了表征。在 HO 的存在下，水凝胶中的 B-C 键可以降解为 B-OH 和 C-OH 单元，从而导致化学水凝胶的降解。己酮可可碱被载入 HNTs-BO 的内腔中，然后得到负载己酮可可碱的水凝胶。药物释放曲线表明，当使用磷酸盐缓冲溶液（PBS）作为释放介质时，溶解的药物不超过 7%。值得注意的是，加入 HO（[HO] = 1×10 M）可以实现完全释放（接近 90%），表明所形成的水凝胶具有很高的 HO 响应性。药物释放结果还表明，通过将己酮可可碱载入 HNTs 的内腔而不是将药物嵌入水凝胶网络中，可以有效抑制“初始突释”。具有 HO 响应性释放行为的载药水凝胶可能在生物医学领域开辟更广阔的应用前景。
