Song Weihua, You Jipeng, Zhang Yuangong, Yang Qi, Jiao Jin, Zhang Hailei
Affiliated Hospital of Hebei University, Baoding 071000, China.
College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China.
Gels. 2022 Jun 8;8(6):361. doi: 10.3390/gels8060361.
HO is essential for cellular processes and plays a vital role in the regulation of cell signaling pathways, which can be viewed as a warning signal for many kinds of disease including cancer, cardiovascular disease, reproductive abnormalities, diabetes, and renal failure. A HO-responsive hydrogel (HO-Gel) is a promising candidate for biomedical applications because of its good biocompatibility, similarity to soft biological tissues, ease of preparation, and its ability to respond to HO. In this study, the HO-responsive moieties used to fabricate HO-Gels were reviewed, including thioethers, disulfide bonds, selenides, diselenium bonds, diketones, boronic, and others. Next, the preparation method of HO-Gel was divided into two major categories according to their reaction mechanisms: either self-crosslinking or mechanisms entailing the addition of difunctional crosslinkers. Last, the applications of HO-Gels were emphasized, which have been viewed as desirable candidates in the fields of drug delivery, the detection of HO, glucose-responsive systems, ROS scavengers, tissue engineering, and cell-encapsulation.
血红素加氧酶（HO）对于细胞过程至关重要，在细胞信号通路的调节中发挥着关键作用，这可被视为包括癌症、心血管疾病、生殖异常、糖尿病和肾衰竭在内的多种疾病的警示信号。一种对HO有响应的水凝胶（HO-Gel）因其良好的生物相容性、与柔软生物组织的相似性、易于制备以及对HO的响应能力，而成为生物医学应用中颇具潜力的候选材料。在本研究中，对用于制备HO-Gels的HO响应基团进行了综述，包括硫醚、二硫键、硒化物、二硒键、二酮、硼酸等。接下来，根据其反应机制，HO-Gel的制备方法分为两大类：自交联或需要添加双官能交联剂的机制。最后，强调了HO-Gels的应用，它们在药物递送、HO检测、葡萄糖响应系统、活性氧清除剂、组织工程和细胞封装等领域被视为理想的候选材料。
