Zegarra-Valdivia Jonathan Adrián
Laboratorio de Neurociencia Cognitiva y Social, Universidad Nacional de San Agustín, Arequipa, Perú. Address: Universidad Nacional de San Agustín, Avenida Venezuela s/n, Arequipa, Perú. Email:
Medwave. 2017 Aug 28;17(7):e7031. doi: 10.5867/medwave.2017.07.7031.
The study of different neurotrophic factors, including insulin-like growth factor-1 (IGF-1), has become relevant in recent years because of its role in brain activity and its potential therapeutic applications. This article reviews IGF-1 in relation to neuropsychiatric disorders such as autism, anxiety, depression, post-traumatic stress disorder and Alzheimer's disease. An exhaustive search of different original articles, clinical, experimental, and review studies was carried out in MEDLINE/PubMed and ScienceDirect databases, selecting 80 high-impact post-2000 publications. It is concluded that despite the many functions of IGF-1 in the developing nervous system as well as in the adult brain that have been studied, especially with animal models, their role in the human brain with neuropsychiatric disorders is not completely understood, yielding contradictory data in highly prevalent disorders such as mood disorders. However, greater implications are encountered with neurodegenerative disorders. In addition, its high potential as a therapeutic resource in difficult-to-approach neuropsychiatric disorders, such as autism and Alzheimer's disease, is pointed out, but more research is needed at both basic and clinical levels, to fully understand its relevance in these disorders.
近年来，包括胰岛素样生长因子-1（IGF-1）在内的不同神经营养因子的研究变得十分重要，这是因为它在大脑活动中的作用及其潜在的治疗应用。本文综述了IGF-1与神经精神疾病的关系，如自闭症、焦虑症、抑郁症、创伤后应激障碍和阿尔茨海默病。我们在MEDLINE/PubMed和ScienceDirect数据库中对不同的原始文章、临床研究、实验研究和综述进行了详尽检索，选取了2000年后发表的80篇高影响力出版物。结论是，尽管IGF-1在发育中的神经系统以及成人大脑中的多种功能已得到研究，尤其是通过动物模型进行的研究，但它在患有神经精神疾病的人类大脑中的作用尚未完全明了，在诸如情绪障碍等高度常见的疾病中产生了相互矛盾的数据。然而，在神经退行性疾病方面发现了其更大的影响。此外，文中指出IGF-1在诸如自闭症和阿尔茨海默病等难以治疗的神经精神疾病中作为治疗资源具有很高的潜力，但在基础和临床层面都需要更多研究，以充分了解其在这些疾病中的相关性。
