Key Laboratory of Preparation and Application of Environmental Friendly Materials (Jilin Normal University), Ministry of Education, Changchun, 130103, PR China.
CAS Key Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, PR China.
Anal Chim Acta. 2017 Sep 8;985:24-40. doi: 10.1016/j.aca.2017.06.054. Epub 2017 Jul 6.
The modification of graphene with biomacromolecules like DNA, protein, peptide, and others extends the potential applications of graphene materials in various fields. The bound biomacromolecules could improve the biocompatibility and bio-recognition ability of graphene-based nanocomposites, therefore could greatly enhance their biosensing performances on both selectivity and sensitivity. In this review, we presented a comprehensive introduction and discussion on recent advance in the synthesis and biosensor applications of graphene-peptide nanocomposites. The biofunctionalization of graphene with specifically designed peptides, and the synthesis strategies of graphene-peptide (monomer, nanofibrils, and nanotubes) nanocomposites were demonstrated. On the other hand, the fabrication of graphene-peptide nanocomposite based biosensor architectures for electrochemical, fluorescent, electronic, and spectroscopic biosensing were further presented. This review includes nearly all the studies on the fabrication and applications of graphene-peptide based biosensors recently, which will promote the future developments of graphene-based biosensors in biomedical detection and environmental analysis.
通过将 DNA、蛋白质、肽等生物大分子修饰到石墨烯上，可以扩展石墨烯材料在各个领域的潜在应用。结合的生物大分子可以提高基于石墨烯的纳米复合材料的生物相容性和生物识别能力，从而极大地提高它们在选择性和灵敏度方面的生物传感性能。在这篇综述中，我们全面介绍和讨论了石墨烯-肽纳米复合材料的合成和生物传感器应用的最新进展。展示了通过专门设计的肽对石墨烯进行生物功能化，以及合成石墨烯-肽（单体、纳米纤维和纳米管）纳米复合材料的策略。另一方面，还进一步介绍了基于石墨烯-肽纳米复合材料的用于电化学生物传感器、荧光生物传感器、电子生物传感器和光谱生物传感器的生物传感器结构的制备。本综述包括了最近关于基于石墨烯的生物传感器的制备和应用的几乎所有研究，这将促进基于石墨烯的生物传感器在生物医学检测和环境分析中的未来发展。
