Singh Udisha, Morya Vinod, Datta Bhaskar, Ghoroi Chinmay, Bhatia Dhiraj
Biological Engineering Discipline, Indian Institute of Technology Gandhinagar, Palaj, India.
Center for Biomedical Engineering, Indian Institute of Technology Gandhinagar, Palaj, India.
Front Chem. 2021 Jun 30;9:704234. doi: 10.3389/fchem.2021.704234. eCollection 2021.
Of the multiple areas of applications of DNA nanotechnology, stimuli-responsive nanodevices have emerged as an elite branch of research owing to the advantages of molecular programmability of DNA structures and stimuli-responsiveness of motifs and DNA itself. These classes of devices present multiples areas to explore for basic and applied science using dynamic DNA nanotechnology. Herein, we take the stake in the recent progress of this fast-growing sub-area of DNA nanotechnology. We discuss different stimuli, motifs, scaffolds, and mechanisms of stimuli-responsive behaviours of DNA nanodevices with appropriate examples. Similarly, we present a multitude of biological applications that have been explored using DNA nanodevices, such as biosensing, pH-mapping, drug delivery, and therapy. We conclude by discussing the challenges and opportunities as well as future prospects of this emerging research area within DNA nanotechnology.
在DNA纳米技术的多个应用领域中，刺激响应性纳米器件因其DNA结构的分子可编程性以及基序和DNA本身的刺激响应性优势，已成为一个卓越的研究分支。这类器件为利用动态DNA纳米技术进行基础科学和应用科学探索提供了多个领域。在此，我们关注DNA纳米技术这一快速发展的子领域的最新进展。我们通过适当的例子讨论DNA纳米器件不同的刺激因素、基序、支架以及刺激响应行为的机制。同样，我们展示了利用DNA纳米器件探索的众多生物应用，如生物传感、pH映射、药物递送和治疗。我们通过讨论DNA纳米技术这一新兴研究领域的挑战与机遇以及未来前景来结束本文。
