Nakada K, Yamaguchi K, Furugen S, Nakasone T, Nakasone K, Oshiro Y, Kohakura M, Hinuma Y, Seiki M, Yoshida M
Int J Cancer. 1987 Aug 15;40(2):145-8. doi: 10.1002/ijc.2910400203.
The relationship between strongyloidiasis and HTLV-I was investigated in Okinawa, an area where both conditions are endemic. Thirty-six patients with strongyloidiasis were seropositive for HTLV-I and suffered from several related clinical complications. Fourteen of these patients (39%) were shown to have monoclonal integration of HTLV-I proviral DNA in their blood lymphocytes, a condition designated as "smouldering" adult T-cell leukaemia (ATL). Monoclonal integration of proviral DNA correlated with an increased CD4/CD8 ratio and the presence of abnormal lymphocytes in the peripheral blood, and with a trend for greater severity of the parasitic infection. Although the immunodeficiency caused by HTLV-I could predispose to hyperinfestation by Strongyloides, it is also possible that both the parasitic and the retroviral infestations are important co-factors leading to the development of ATL.
在两种疾病均为地方病的冲绳地区，对类圆线虫病与人类嗜T淋巴细胞病毒I型（HTLV-I）之间的关系进行了调查。36名类圆线虫病患者HTLV-I血清呈阳性，并患有多种相关临床并发症。其中14名患者（39%）的血液淋巴细胞中显示有HTLV-I前病毒DNA的单克隆整合，这种情况被称为“隐匿性”成人T细胞白血病（ATL）。前病毒DNA的单克隆整合与外周血中CD4/CD8比值升高、异常淋巴细胞的存在相关，也与寄生虫感染更严重的趋势相关。虽然HTLV-I引起的免疫缺陷可能易导致类圆线虫的重度感染，但寄生虫感染和逆转录病毒感染也都有可能是导致ATL发生的重要共同因素。
