Kondratyeva L G, Chernov I P, Zinovyeva M V, Kopantzev E P, Sverdlov E D
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Dokl Biochem Biophys. 2017 Jul;475(1):250-252. doi: 10.1134/S1607672917040020. Epub 2017 Sep 2.
The expression level of some important master regulators of embryonic development of the pancreas in the tumor samples of this human organ was determined. We found that the transcription of SOX9, GATA4, PDX1, PTF1a, and HNF1b genes in the tumor samples was reduced as compared to the samples of normal pancreatic tissues, and the KLF5 gene expression in the tumor cells was elevated. We assume that all the studied genes, except KLF5, form a single regulatory module that supports the identity of tumor progenitor cells. A simultaneous suppression of expression of these master factors may be critical for the neoplastic transformation of pancreatic cells.
测定了该人体器官肿瘤样本中胰腺胚胎发育的一些重要主调控因子的表达水平。我们发现，与正常胰腺组织样本相比，肿瘤样本中SOX9、GATA4、PDX1、PTF1a和HNF1b基因的转录减少，而肿瘤细胞中KLF5基因的表达升高。我们推测，除KLF5外，所有研究的基因形成一个单一的调控模块，该模块维持肿瘤祖细胞的特性。这些主调控因子表达的同时抑制可能对胰腺细胞的肿瘤转化至关重要。
