Mazzeranghi F, Zanotti C, Di Cerbo A, Verstegen J P, Cocco R, Guidetti G, Canello S
, Traversa I di via Rudiano 9/e.
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Pol J Vet Sci. 2017 Mar 1;20(2):269-276. doi: 10.1515/pjvs-2017-0032.
Food allergies and food intolerances are clinically difficult to discriminate. Most often, along with cutaneous adverse food reactions or CAFR, they are classified as adverse food reactions, whose causes are numerous, including toxic compounds. Eighteen indoor-housed domestic cats with evident clinical symptoms related to CAFR (drooling, back and neck intense itching, neck eczema, chronic conjunctivitis and stomatitis) involving skin lesions were studied. Cytological evaluations of ear, skin and gingival swabs revealed an increased turnover of keratinocytes while the oxytetracycline ELISA determination showed an unexpected high amount of oxytetracycline in all cats at the first visit. All cats were then randomly assigned to receive a standard (SD group) or a nutraceutical diet (ND group) for 60 days. In the ND group a significant reduction of the mean serum concentration of oxytetracycline, pruritus intensity and skin lesion severity (**p<0.01, ***p<0.001, and ***p<0.001, respectively) was observed after 60 days, and associated with a significant improvement in the clinical picture. Although a direct correlation between oxytetracycline presence within cat sera and CAFR-related symptoms has never been described, this study highlights the benefit of a specific nutraceutical diet supplementation in improving clinical symptoms and skin lesions in cats with CARF.
食物过敏和食物不耐受在临床上很难区分。通常，除了皮肤性食物不良反应（CAFR）外，它们还被归类为食物不良反应，其病因众多，包括有毒化合物。对18只室内饲养的家猫进行了研究，这些猫有明显的与CAFR相关的临床症状（流口水、背部和颈部剧烈瘙痒、颈部湿疹、慢性结膜炎和口腔炎），且伴有皮肤病变。对耳部、皮肤和牙龈拭子的细胞学评估显示角质形成细胞周转率增加，而土霉素酶联免疫吸附测定显示在首次就诊时所有猫体内土霉素含量意外地高。然后将所有猫随机分为两组，分别接受标准饮食（SD组）或营养补充剂饮食（ND组），为期60天。60天后，在ND组中观察到土霉素的平均血清浓度、瘙痒强度和皮肤病变严重程度均显著降低（分别为**p<0.01、p<0.001和p<0.001），并且临床症状有显著改善。尽管从未描述过猫血清中土霉素的存在与CAFR相关症状之间的直接关联，但本研究强调了特定营养补充剂饮食对改善患有CARF的猫的临床症状和皮肤病变的益处。
