Eskilsson Therese, Slunga Järvholm Lisbeth, Malmberg Gavelin Hanna, Stigsdotter Neely Anna, Boraxbekk Carl-Johan
Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, SE- 901 87, Umeå, Sweden.
Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden.
BMC Psychiatry. 2017 Sep 2;17(1):322. doi: 10.1186/s12888-017-1457-1.
Patients with stress-related exhaustion suffer from cognitive impairments, which often remain after psychological treatment or work place interventions. It is important to find effective treatments that can address this problem. Therefore, the aim of this study was to investigate the effects on cognitive performance and psychological variables of a 12-week aerobic training program performed at a moderate-vigorous intensity for patients with exhaustion disorder who participated in a multimodal rehabilitation program.
In this open-label, parallel, randomized and controlled trial, 88 patients diagnosed with exhaustion disorder participated in a 24-week multimodal rehabilitation program. After 12 weeks in the program the patients were randomized to either a 12-week aerobic training intervention or to a control group with no additional training. Primary outcome measure was cognitive function, and secondary outcome measures were psychological health variables and aerobic capacity.
In total, 51% patients in the aerobic training group and 78% patients in the control group completed the intervention period. The aerobic training group significantly improved in maximal oxygen uptake and episodic memory performance. No additional improvement in burnout, depression or anxiety was observed in the aerobic group compared with controls.
Aerobic training at a moderate-vigorous intensity within a multimodal rehabilitation program for patients with exhaustion disorder facilitated episodic memory. A future challenge would be the clinical implementation of aerobic training and methods to increase feasibility in this patient group.
ClinicalTrials.gov: NCT03073772 . Retrospectively registered 21 February 2017.
与压力相关的疲惫患者存在认知障碍，在心理治疗或工作场所干预后，这些障碍往往依然存在。找到能够解决这一问题的有效治疗方法很重要。因此，本研究的目的是调查一项为期12周、以中高强度进行的有氧训练计划，对参与多模式康复计划的疲惫障碍患者认知表现和心理变量的影响。
在这项开放标签、平行、随机对照试验中，88名被诊断为疲惫障碍的患者参与了一项为期24周的多模式康复计划。在该计划进行12周后，患者被随机分为两组，一组接受为期12周的有氧训练干预，另一组为不进行额外训练的对照组。主要结局指标是认知功能，次要结局指标是心理健康变量和有氧能力。
有氧训练组共有51%的患者以及对照组78%的患者完成了干预期。有氧训练组的最大摄氧量和情景记忆表现显著改善。与对照组相比，有氧训练组在倦怠、抑郁或焦虑方面未观察到进一步改善。
在针对疲惫障碍患者的多模式康复计划中，中高强度的有氧训练促进了情景记忆。未来的一个挑战将是有氧训练的临床实施以及提高该患者群体可行性的方法。
ClinicalTrials.gov：NCT03073772。于2017年2月21日进行回顾性注册。
