Smolensky Michael H, Hermida Ramón C, Ayala Diana E, Mojón Artemio, Fernández José R
Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, 1 University Station C0800, Austin, TX 78712-0238, USA.
Bioengineering & Chronobiology Laboratories, Atlantic Research Center for Information and Communication Technologies (AtlantTIC), University of Vigo, 36310 Vigo, Spain.
Heart Fail Clin. 2017 Oct;13(4):775-792. doi: 10.1016/j.hfc.2017.05.011. Epub 2017 Jul 13.
The bases for bedtime hypertension chronotherapy (BHCT) as superior chronoprevention against cardiovascular disease (CVD) are: (1) correlation between blood pressure (BP) and various risks is greater for ambulatory BP monitoring (ABPM) than office BP measurements (OBPM); (2) asleep BP mean is a better predictor of CVD risk than ABPM awake and 24-hour means and OBPM; and (3) targeting of asleep BP by BHCT with one or more conventional medications versus usual on-awakening therapy better reduces major and total CVD events. BHCT offers the most cost-effective chronoprevention against adverse CVD outcomes in regular and vulnerable renal, diabetic, and resistant hypertensive patients.
作为预防心血管疾病（CVD）的更优时辰疗法，睡前高血压时辰疗法（BHCT）的依据如下：（1）动态血压监测（ABPM）所测血压（BP）与各种风险之间的相关性高于诊室血压测量（OBPM）；（2）睡眠期间平均血压比ABPM清醒时及24小时平均血压和OBPM更能预测CVD风险；（3）与常规晨起治疗相比，使用一种或多种传统药物通过BHCT靶向睡眠期间血压能更好地减少主要和总的CVD事件。对于普通及易患肾病、糖尿病和顽固性高血压患者，BHCT在预防不良CVD结局方面提供了最具成本效益的时辰疗法。
