血红蛋白在钯-石墨烯修饰电极上的直接电化学及电催化行为研究
Investigation on direct electrochemical and electrocatalytic behavior of hemoglobin on palladium-graphene modified electrode.
作者信息
Chen Wei, Niu Xueliang, Li Xiaoyan, Li Xiaobao, Li Guangjiu, He Bolin, Li Qiutong, Sun Wei
机构信息
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
出版信息
Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:135-140. doi: 10.1016/j.msec.2017.05.129. Epub 2017 May 21.
Palladium-graphene (Pd-GR) nanocomposite was acted as modifier for construction of the modified electrode with direct electrochemistry of hemoglobin (Hb) realized. By using Nafion as the immobilization film, Hb was fixed tightly on Pd-GR nanocomposite modified carbon ionic liquid electrode. Electrochemical behaviors of Hb modified electrode were checked by cyclic voltammetry and a pair of redox peaks originated from direct electron transfer of Hb was appeared. The Hb modified electrode had excellent electrocatalytic activity to the reduction of trichloroacetic acid and sodium nitrite in the concentration range from 0.6 to 13.0mmol·L and from 0.04 to 0.5 mmol·L. Therefore Pd-GR nanocomposite was proven to be a good candidate for the fabrication of third-generation electrochemical biosensor.
钯-石墨烯（Pd-GR）纳米复合材料用作修饰剂构建修饰电极，实现了血红蛋白（Hb）的直接电化学。以Nafion作为固定膜，Hb被紧密固定在Pd-GR纳米复合材料修饰的碳离子液体电极上。通过循环伏安法检测Hb修饰电极的电化学行为，出现了一对源于Hb直接电子转移的氧化还原峰。Hb修饰电极对浓度范围为0.6至13.0mmol·L的三氯乙酸和浓度范围为0.04至0.5 mmol·L的亚硝酸钠的还原具有优异的电催化活性。因此，Pd-GR纳米复合材料被证明是制备第三代电化学生物传感器的良好候选材料。
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