University School of Basic and Applied Sciences, Guru Gobind Singh Indraprastha University, Sector 16-C, Dwarka, New Delhi 110078, India.
National Physical Laboratory, Dr K.S. Krishnan Road, New Delhi 110012, India.
Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:274-281. doi: 10.1016/j.msec.2017.05.079. Epub 2017 May 14.
In this paper we report synthesis of aqueous based gold coated iron oxide nanoparticles to integrate the localized surface plasma resonance (SPR) properties of gold and magnetic properties of iron oxide in a single system. Iron oxide-gold core shell nanoparticles were stabilized by attachment of thiolated sodium alginate to the surface of nanoparticles. Transmission electron microscope (TEM) micrograph presents an average elementary particle size of 8.1±2.1nm. High resolution TEM (HR-TEM) and X-ray photon spectroscopy further confirms the presence of gold shell around iron oxide core. Gold coating is responsible for reducing saturation magnetization (M) value from ~41emu/g to ~24emu/g - in thiolated sodium alginate stabilized gold coated iron oxide core-shell nanoparticles. The drug (curcumin) loading efficiency for the prepared nanocomposites was estimated to be around 7.2wt% (72μgdrug/mg nanoparticles) with encapsulation efficiency of 72.8%. Gold-coated iron oxide core-shell nanoparticles could be of immense importance in the field of targeted drug delivery along with capability to be used as contrast agent for MRI & CT.
本文报道了一种基于水相的金包覆氧化铁纳米粒子的合成方法，旨在将金的局域表面等离子体共振（SPR）性质和氧化铁的磁性集成在一个单一的系统中。通过将巯基化的海藻酸钠附着到纳米粒子的表面，氧化铁-金核壳纳米粒子得到了稳定。透射电子显微镜（TEM）照片显示平均基本粒子尺寸为 8.1±2.1nm。高分辨率 TEM（HR-TEM）和 X 射线光电子能谱进一步证实了金壳在氧化铁核周围的存在。金包覆层使饱和磁化强度（M）值从41emu/g 降低至24emu/g-在巯基化的海藻酸钠稳定的金包覆氧化铁核壳纳米粒子中。所制备的纳米复合材料的药物（姜黄素）负载效率估计约为 7.2wt%（72μgdrug/mg 纳米粒子），封装效率为 72.8%。金包覆氧化铁核壳纳米粒子在靶向药物输送领域可能具有重要意义，并且能够用作 MRI 和 CT 的对比剂。
