Rehan Mohamed, Zaghloul S, Mahmoud F A, Montaser A S, Hebeish A
Textile Research Division, Pre-treatment and Finishing of Cellulosic Fibers Department, National Research Centre, 33 Bohoth Street, Dokki, P.O. Box 12622, Cairo, Egypt.
Textile Research Division, Pre-treatment and Finishing of Cellulosic Fibers Department, National Research Centre, 33 Bohoth Street, Dokki, P.O. Box 12622, Cairo, Egypt.
Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:29-37. doi: 10.1016/j.msec.2017.05.093. Epub 2017 May 15.
The ideal biomedical fiber/fabric materials can both promote the drug delivery properties and prevent microbial infection. Herein we present an innovation-based strategy for fabrication of biomedical cotton gauze which concomitantly displays antimicrobial and drug delivery performance properties. The innovative strategy involved three distinct steps: (1) Cationization of cotton gauze by reacting it with 3-chloro-2-hydroxypropyl trimethyl ammonium chloride [Quat-188] or anionization of cotton gauze through partial carboxymethylation. (2) Thus modified samples of cotton gauze along with unmodified blank samples were submitted to in situ formation of silver nanoparticles (AgNPs) using trisodium citrate (TSC) which has three-fold functions: (a) reducing agent for conversion of Ag to Ag (atom), (b) stabilizing agent to prevent aggregation of AgNPs and, (c) linker for fixation of AgNPs on the surfaces of the cotton gauze. (3) All the modified and unmodified cotton gauze samples were loaded with oxytetracyline hydrochloride drug. To this end, characterization of the modified and unmodified cotton samples before and after being loaded with drug using state-of-the-art facilities was undertaken. These facilities comprised UV-vis spectroscopy, energy dispersive X-ray, scanning electron microscope and Infrared Spectroscopy by Attenuated total Reflectance (ATR/IR). Evaluation of the antimicrobial and drug release properties of the cotton gauze samples in question was conducting. Results obtained signified that the modified cotton gauze can be used in the area of biomedical textiles particularly as antimicrobial and drug delivery. Also reported were mechanisms entailed in chemical modifications of cotton gauze and interactions of this modified cotton gauze with antimicrobial as well as with drugs.
理想的生物医学纤维/织物材料既能促进药物递送性能，又能预防微生物感染。在此，我们提出一种基于创新的生物医学棉纱制造策略，该棉纱同时具有抗菌和药物递送性能。创新策略包括三个不同步骤：（1）使棉纱与3-氯-2-羟丙基三甲基氯化铵[季铵盐-188]反应进行阳离子化，或通过部分羧甲基化使棉纱阴离子化。（2）使用具有三重功能的柠檬酸钠（TSC）将如此改性的棉纱样品以及未改性的空白样品用于原位形成银纳米颗粒（AgNP）：（a）将Ag转化为Ag（原子）的还原剂，（b）防止AgNP聚集的稳定剂，以及（c）将AgNP固定在棉纱表面的连接剂。（3）所有改性和未改性的棉纱样品都负载盐酸土霉素药物。为此，使用最先进的设备对负载药物前后的改性和未改性棉花样品进行表征。这些设备包括紫外可见光谱、能量色散X射线、扫描电子显微镜和衰减全反射红外光谱（ATR/IR）。对所讨论的棉纱样品的抗菌和药物释放性能进行了评估。获得的结果表明，改性棉纱可用于生物医学纺织品领域，特别是作为抗菌和药物递送材料。还报道了棉纱化学改性所涉及的机制以及这种改性棉纱与抗菌剂和药物的相互作用。
