Institute of Material Science of Textiles and Polymer Composites, Lodz University of Technology, Żeromskiego 116, 90-543, Lodz, Poland.
Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363, Lodz, Poland.
Sci Rep. 2024 Mar 27;14(1):7310. doi: 10.1038/s41598-024-57883-5.
This paper presents active analgesic and anti-inflammatory dressings based on cotton woven material with surface functionalization enabling drug implementation. For this purpose, lactide was polymerized on the surface of cotton textiles to achieve better compatibility with hydrophobic drug and polylactide (PLA)-based macromolecules. Subsequently, ibuprofen-loaded PLA and PLA-PEG were implemented through the exhausting method. Such material was tested for cytotoxicity (toward L929 mouse fibroblasts) and anti-inflammatory activity (towards human Hs68 fibroblasts) based on the secretion of pro-inflammatory cytokines IL-1β and TNF-α. The results showed that the drug attachment and its performance are influenced by a combination of mercerization, bleaching and polylactide grafting, and the release of ibuprofen depends on the drug-loaded layer structure. Moreover, we show that cotton woven fabric with ibuprofen-loaded PLA and PLA-PEG cover layers had anti-inflammatory properties. These new dressings may open possibilities for developing prolonged analgesic and anti-inflammatory materials for wound healing or transdermal drug delivery.
本文提出了基于棉织材料的主动止痛和抗炎敷料，其表面功能化可实现药物的应用。为此，在棉纺织品表面聚合丙交酯以实现与疏水性药物和基于聚乳酸（PLA）的大分子更好的相容性。随后，通过耗尽法实现了载有布洛芬的 PLA 和 PLA-PEG。根据促炎细胞因子 IL-1β 和 TNF-α 的分泌，对这种材料的细胞毒性（对 L929 小鼠成纤维细胞）和抗炎活性（对人 Hs68 成纤维细胞）进行了测试。结果表明，药物的附着及其性能受丝光、漂白和聚乳酸接枝的组合影响，布洛芬的释放取决于药物负载层的结构。此外，我们还表明，载有 PLA 和 PLA-PEG 覆盖层的布洛芬的机织织物具有抗炎特性。这些新型敷料可能为开发用于伤口愈合或透皮药物输送的长效止痛和抗炎材料开辟可能性。
