State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, PR China.
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, PR China.
Int J Biol Macromol. 2018 Feb;107(Pt A):230-235. doi: 10.1016/j.ijbiomac.2017.08.175. Epub 2017 Sep 1.
Dendrobium nobile is a medicinal herb in traditional China and Southeast Asian countries. Employing a rat model of ethanol-induced gastric ulcer, we examined the protective effect of polysaccharide (JCP) extracted from Dendrobium nobile and explored the related mechanisms. Oral administration with 100mg/kg and 300mg/kg body weight JCP for days can significant prevent the formation of gastric ulcer. Moreover, JCP pretreatment could alleviate ethanol-induced histological damage, antioxidant activities, the level of epidermal growth factor, gastric concentration of prostaglandin E, and regulate the signaling pathways of mitogen-activated protein kinases and matrix metalloproteinases. This study investigated the ethanol-induced gastric ulcer protective effect of JCP for the first time, and elucidated that the protective mechanisms.
铁皮石斛是中国传统医学和东南亚国家的一种药用草本植物。我们采用乙醇诱导的大鼠胃溃疡模型，研究了铁皮石斛多糖（JCP）的保护作用，并探讨了相关机制。铁皮石斛多糖（JCP）经口给予 100mg/kg 和 300mg/kg 体重时，可显著预防胃溃疡的形成。此外，JCP 预处理可减轻乙醇诱导的组织学损伤、抗氧化活性、表皮生长因子水平、胃前列腺素 E 浓度，并调节丝裂原活化蛋白激酶和基质金属蛋白酶的信号通路。本研究首次探讨了 JCP 对乙醇诱导的胃溃疡的保护作用及其机制。
