Department of Pediatrics- Neonatology, Medical University of South Carolina, 165 Ashley Avenue, MSC 971 Charleston, SC 29425, USA.
Department of Pediatrics- Neonatology, Medical University of South Carolina, 165 Ashley Avenue, MSC 971 Charleston, SC 29425, USA.
J Steroid Biochem Mol Biol. 2018 Mar;177:261-265. doi: 10.1016/j.jsbmb.2017.08.015. Epub 2017 Sep 1.
Existing research shows an association between physical activity levels and vitamin D status in the elderly, men, women, children, and adolescent populations. This association has not yet been investigated in postpartum women. We hypothesized that based on the relationship between vitamin D and physical activity found in other populations, greater physical activity levels in postpartum women will be associated with higher serum 25(OH)D levels. A post hoc analysis of 286 postpartum women with self reported physical activity data from the America on the Move survey, and measured circulating serum 25(OH)D (measured by RIA) as an indicator of vitamin D status, was gathered at baseline (4-6 weeks postpartum), 4 months, and 7 months postpartum. The data were analyzed using SAS 9.4 (Cary, NC). 39.9% of women at visit 1 (baseline), 52.8% of women at visit 4 (month 4), and 55.9% of women at visit 7 (month 7) were meeting the NIH recommendation of 150min of moderate intensity (3-6 METs) physical activity per week. Significant differences were seen in physical activity by race (p=0.007). Caucasians were more likely to meet the standard recommendation than African Americans or Hispanics. Using multiple regression models to examine associations between duration of physical activity and 25(OH)D concentration, controlling for race, BMI, feeding type, and METs, it was found that at visit 1, an increase in physical activity was associated with an increase in 25(OH)D of 1.3nmol/L (p=0.03) and achieving at least 2.5h/wk of physical activity had a trending association with an increase in 25(OH)D of 7.23nmol/L (p=.05). At visit 4 (also controlling for treatment group and sun exposure) achieving at least 1.5h/wk of physical activity was associated with an increase in 25(OH)D of 11.73nmol/L (p=.04). By visit 7, no association between physical activity and maternal 25(OH)D was observed. In a repeated measures, mixed model analysis predicting maternal 25(OH)D during the study, achieving at least the recommended 150min per week of physical activity (>2.5h) was not significantly associated with vitamin D status (pNS). While no definitive conclusions can be drawn regarding precise levels of physical activity influencing 25(OH)D levels in postpartum women, the data suggest that increased activity during the first 4 months after birth is associated with improved vitamin D status. Additional research is needed because of the inconsistency seen at visit 7.
现有研究表明，体力活动水平与老年人、男性、女性、儿童和青少年人群的维生素 D 状况之间存在关联。然而，这种关联尚未在产后女性中进行研究。我们假设，基于其他人群中发现的维生素 D 与体力活动之间的关系，产后女性的体力活动水平越高，其血清 25(OH)D 水平就会越高。对美国运动调查中自我报告体力活动数据的 286 名产后女性进行了事后分析，并在基线（产后 4-6 周）、4 个月和 7 个月时测量了循环血清 25(OH)D（通过 RIA 测量）作为维生素 D 状态的指标。数据使用 SAS 9.4（Cary，NC）进行分析。在第 1 次就诊（基线）时，有 39.9%的女性、第 4 次就诊（第 4 个月）时 52.8%的女性和第 7 次就诊（第 7 个月）时 55.9%的女性达到了 NIH 每周 150 分钟中等强度（3-6 METs）体力活动的推荐量。不同种族之间的体力活动存在显著差异（p=0.007）。与非裔美国人和西班牙裔相比，白种人更有可能达到标准建议。使用多元回归模型来检查体力活动持续时间与 25(OH)D 浓度之间的关联，同时控制种族、BMI、喂养类型和 METs，结果发现，在第 1 次就诊时，体力活动的增加与 25(OH)D 的增加呈正相关，增加 1.3nmol/L（p=0.03），每周至少进行 2.5 小时的体力活动与 25(OH)D 增加 7.23nmol/L 呈趋势相关（p=0.05）。在第 4 次就诊时（同时控制治疗组和阳光暴露），每周至少进行 1.5 小时的体力活动与 25(OH)D 增加 11.73nmol/L 呈正相关（p=0.04）。到第 7 次就诊时，体力活动与产妇 25(OH)D 之间没有观察到关联。在一项预测研究期间产妇 25(OH)D 的重复测量混合模型分析中，每周至少进行推荐的 150 分钟体力活动（>2.5 小时）与维生素 D 状态没有显著相关性（pNS）。虽然不能确定产后女性体力活动的确切水平对 25(OH)D 水平的影响，但数据表明，在分娩后前 4 个月增加活动与改善维生素 D 状态有关。由于第 7 次就诊时出现不一致，因此需要进一步研究。
