Dahl Kenneth, Ulin Johan, Schou Magnus, Halldin Christer
Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Stockholm, Sweden.
AstraZeneca PET Science Centre, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
J Labelled Comp Radiopharm. 2017 Nov;60(13):624-628. doi: 10.1002/jlcr.3561. Epub 2017 Oct 19.
A new method for the reduction of no-carrier-added [ C]carbon dioxide into [ C]carbon monoxide ([ C]CO) is described, in which the reductant (zinc) is supported on fused silica particles. Using this setup, which allows for a reduction temperature (485°C) well above the melting point for zinc (420°C), radiochemical yields of up to 96% (decay-corrected) were obtained. A slight decrease in radiochemical yield was observed upon repeated [ C]CO productions (93 ± 3%, n = 20). The methodology is convenient and efficient and provides a straightforward path to no-carrier-added production of [ C]CO.
本文描述了一种将无载体添加的[C]二氧化碳还原为[C]一氧化碳（[C]CO）的新方法，其中还原剂（锌）负载在熔融石英颗粒上。使用这种装置，还原温度（485°C）远高于锌的熔点（420°C），可获得高达96%（经衰变校正）的放射化学产率。在重复生产[C]CO时，观察到放射化学产率略有下降（93±3%，n = 20）。该方法简便高效，为无载体添加生产[C]CO提供了一条直接途径。
