由[¹¹C]硅烷介导的[¹¹C]CO₂向[¹¹C]CO的转化：一种用于[¹¹C]羰基化反应的新途径。
[(11)C]CO2 to [(11)C]CO conversion mediated by [(11)C]silanes: a novel route for [(11)C]carbonylation reactions.
作者信息
Taddei Carlotta, Bongarzone Salvatore, Haji Dheere Abdul Karim, Gee Antony D
机构信息
Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London, SE1 7EH, UK.
出版信息
Chem Commun (Camb). 2015 Jul 28;51(59):11795-11797. doi: 10.1039/c5cc02095f.
A novel chemical methodology is described for the conversion of [(11)C]CO2 to [(11)C]CO. Diphenylmethyl silanes trap [(11)C]CO2 and release [(11)C]CO rapidly when triggered by TBAF. Released [(11)C]CO was used to produce [(11)C]N-benzylbenzamide and AMPA receptor ligand, [(11)C], in radiochemical yields >90% within 6 min from [(11)C]CO2 production.
描述了一种将[(11)C]CO2转化为[(11)C]CO的新型化学方法。二苯基甲基硅烷捕获[(11)C]CO2，并在四丁基氟化铵（TBAF）触发下迅速释放[(11)C]CO。释放出的[(11)C]CO用于制备[(11)C]N-苄基苯甲酰胺和AMPA受体配体[(11)C]，从[(11)C]CO2产生开始，在6分钟内放射化学产率>90%。
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