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[粪便微生物群移植治疗肠道疾病]

[Faecal microbiota transplantation for the treatment of bowel disease].

作者信息

Rode Anne A, Chehri Mahtab, Petersen Andreas Munk, Bytzer Peter

出版信息

Ugeskr Laeger. 2017 Jul 31;179(31).

PMID:28869008
Abstract

Faecal microbiota transplantation (FMT) is the transferral of faeces from a healthy donor to a patient with a disease linked to disturbances in the gut microbiota. The treatment has been implemented at several hospitals in Denmark, and banks with frozen donor stool material have been established. The effect of FMT for recurrent Clostridium difficile infection is well-documented. FMT cannot be recommended for routine clinical use for inflammatory bowel disease and irritable bowel syndrome because of lack of data from clinical trials.

摘要

粪便微生物群移植(FMT)是将健康供体的粪便转移到患有与肠道微生物群紊乱相关疾病的患者体内。丹麦的几家医院已经实施了这种治疗方法,并且建立了储存冷冻供体粪便样本的库。FMT对复发性艰难梭菌感染的疗效已有充分记录。由于缺乏临床试验数据,不建议将FMT用于炎症性肠病和肠易激综合征的常规临床治疗。

相似文献

1
[Faecal microbiota transplantation for the treatment of bowel disease].[粪便微生物群移植治疗肠道疾病]
Ugeskr Laeger. 2017 Jul 31;179(31).
2
Fecal Microbiota Transplantation.粪便微生物群移植
Gastroenterol Clin North Am. 2017 Mar;46(1):171-185. doi: 10.1016/j.gtc.2016.09.012.
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Clinical Application and Potential of Fecal Microbiota Transplantation.粪便微生物移植的临床应用和潜力。
Annu Rev Med. 2019 Jan 27;70:335-351. doi: 10.1146/annurev-med-111717-122956. Epub 2018 Nov 7.
4
Fecal microbiota transplantation: past, present and future perspectives.粪便微生物群移植:过去、现在和未来展望
Minerva Gastroenterol Dietol. 2017 Dec;63(4):420-430. doi: 10.23736/S1121-421X.17.02374-1.
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Fecal microbiota transplantation as a new therapy: from Clostridioides difficile infection to inflammatory bowel disease, irritable bowel syndrome, and colon cancer.粪便微生物群移植作为一种新疗法:从艰难梭菌感染到炎症性肠病、肠易激综合征和结肠癌。
Curr Opin Pharmacol. 2019 Dec;49:43-51. doi: 10.1016/j.coph.2019.04.017. Epub 2019 Jun 5.
6
Current applications of fecal microbiota transplantation in intestinal disorders.粪便微生物群移植在肠道疾病中的应用现状。
Kaohsiung J Med Sci. 2019 Jun;35(6):327-331. doi: 10.1002/kjm2.12069. Epub 2019 Apr 24.
7
Fecal microbiota transplantation in recurrent Clostridium difficile infection in a patient with concomitant inflammatory bowel disease.粪便微生物群移植治疗合并炎症性肠病的复发性艰难梭菌感染患者
Rev Esp Enferm Dig. 2017 Jun;109(6):473-476. doi: 10.17235/reed.2017.4819/2016.
8
Irritable Bowel Syndrome-Like Symptoms Following Fecal Microbiota Transplantation: A Possible Donor-Dependent Complication.粪便微生物群移植后类似肠易激综合征的症状:一种可能的供体依赖性并发症。
Am J Gastroenterol. 2017 Jan;112(1):186-187. doi: 10.1038/ajg.2016.472.
9
Fecal microbial transplantation: an update.粪便微生物移植:更新。
Curr Opin Clin Nutr Metab Care. 2018 Sep;21(5):405-410. doi: 10.1097/MCO.0000000000000488.
10
Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammatory bowel disease.在儿童中,单次粪便微生物群移植后,艰难梭菌持续根除与微生物组变化的关系,无论是否患有炎症性肠病。
Aliment Pharmacol Ther. 2015 Sep;42(6):741-52. doi: 10.1111/apt.13326. Epub 2015 Jul 21.

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