Department of Gastroenterology and Hepatology, and Department of Medical Microbiology and Infection Control, VU University Medical Center, 1181 HZ, Amsterdam, The Netherlands.
Department of Medical Microbiology, Center for Infectious Diseases, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Annu Rev Med. 2019 Jan 27;70:335-351. doi: 10.1146/annurev-med-111717-122956. Epub 2018 Nov 7.
Fecal microbiota transplantation (FMT) is a well-established treatment for recurrent Clostridioides difficile infection. FMT has become a more readily available and useful new treatment option as a result of stool banks. The current state of knowledge indicates that dysbiosis of the gut microbiota is implicated in several disorders in addition to C. difficile infection. Randomized controlled studies have shown FMT to be somewhat effective in treating ulcerative colitis, irritable bowel syndrome, and hepatic encephalopathy. In addition, FMT has been beneficial in treating several other conditions, such as the eradication of multidrug-resistant organisms and graft-versus-host disease. We expect that FMT will soon be implemented as a treatment strategy for several new indications, although further studies are needed.
粪便微生物群移植（FMT）是治疗复发性艰难梭菌感染的一种成熟的治疗方法。由于粪便库的出现，FMT 已成为一种更易于获得和有用的新治疗选择。目前的知识状况表明，肠道微生物群的失调除了与艰难梭菌感染有关外，还与几种疾病有关。随机对照研究表明，FMT 在治疗溃疡性结肠炎、肠易激综合征和肝性脑病方面具有一定的疗效。此外，FMT 在治疗其他几种疾病方面也有益，例如消除多药耐药菌和移植物抗宿主病。我们预计 FMT 将很快被用作几种新适应症的治疗策略，尽管还需要进一步的研究。
