Šuca H, Zajíček R, Vodsloň Z
Acta Chir Plast. 2017 Summer;59(1):33-36.
Microneedling (percutaneous collagen induction therapy) is a new promising miniinvasive therapeutic method for the treatment of skin alterations of different aetiology, including burn scars. Since 2016, it is also available at our department. The microtraumatization of scars with the Dermaroller® leads to an activation of the healing cascade, activation of growth factors, which activate cell proliferation in the wound, increased synthesis and deposit of collagen - elastin complex with successive transformation of collagen III to collagen I, to neoangiogenesis and thus to accelerated scar remodelling.
In the pilot study conducted in 2016, the microneedling method with Dermaroller® with 2.5 mm needles was used in six patients (two males, four females; age 25-73 years) with stabilized scars after previous application of split thickness skin graft due to thermal injury. We repeated the microneedling procedure in three intervals approximately 6 to 8 weeks apart, with the use of topical anaesthesia.
Preliminary results showed a subjective improvement of the scars. Objective evaluation with the Vancouver Scar Score showed an improvement of an average of two points before and after treatment.
Our first clinical experience show that microneedling appears to be a suitable microinvasive method for the improvement of scar quality after burn trauma.
微针疗法（经皮胶原诱导疗法）是一种新的、有前景的微创治疗方法，用于治疗不同病因引起的皮肤改变，包括烧伤瘢痕。自2016年起，我们科室也开始采用该疗法。使用 Dermaroller® 对瘢痕进行微创伤处理可激活愈合级联反应，激活生长因子，这些生长因子可激活伤口处的细胞增殖，增加胶原蛋白 - 弹性蛋白复合物的合成与沉积，并使胶原蛋白III相继转化为胶原蛋白I，促进新生血管形成，从而加速瘢痕重塑。
在2016年进行的一项初步研究中，对6例（2例男性，4例女性；年龄25 - 73岁）因热损伤曾接受过中厚皮片移植且瘢痕已稳定的患者，使用了配有2.5毫米针头的 Dermaroller® 微针疗法。我们每隔约6至8周重复进行三次微针治疗，并使用局部麻醉。
初步结果显示瘢痕有主观改善。采用温哥华瘢痕评分进行的客观评估表明，治疗前后平均改善了两分。
我们的首次临床经验表明，微针疗法似乎是一种改善烧伤创伤后瘢痕质量的合适微创方法。
