Wahl S M, Hunt D A, Wakefield L M, McCartney-Francis N, Wahl L M, Roberts A B, Sporn M B
Proc Natl Acad Sci U S A. 1987 Aug;84(16):5788-92. doi: 10.1073/pnas.84.16.5788.
Recent studies have focused on the potential role of transforming growth factor type beta (TGF-beta) as an immunoregulatory peptide. In this context, we demonstrate that TGF-beta is a potent chemoattractant for human peripheral blood monocytes. At concentrations from 0.1 to 10 pg/ml, TGF-beta induces directed monocyte migration in vitro. Consistent with this observation is the expression of high-affinity TGF-beta receptors on the monocytes with a Kd of 1-10 pM. At higher concentrations of TGF-beta (greater than or equal to 1 ng/ml), monocytes are stimulated to generate biologically active mediator(s) that enhance fibroblast growth. Gene expression for one of these growth factors, interleukin 1, is induced in monocytes within hours after exposure to TGF-beta. Thus, TGF-beta may provide an important signal for monocyte recruitment and for regulation of their synthesis of mediators of fibroblast growth and activity in wound healing.
最近的研究聚焦于转化生长因子β（TGF-β）作为一种免疫调节肽的潜在作用。在此背景下，我们证明TGF-β是人类外周血单核细胞的一种强效趋化因子。在0.1至10 pg/ml的浓度范围内，TGF-β在体外诱导单核细胞定向迁移。与此观察结果一致的是，单核细胞上存在高亲和力的TGF-β受体，其解离常数为1-10 pM。在更高浓度的TGF-β（大于或等于1 ng/ml）作用下，单核细胞被刺激产生增强成纤维细胞生长的生物活性介质。这些生长因子之一白细胞介素1的基因表达在单核细胞暴露于TGF-β后数小时内被诱导。因此，TGF-β可能为单核细胞募集以及调节其在伤口愈合中合成成纤维细胞生长和活性介质提供重要信号。
