Sporn M B, Roberts A B, Shull J H, Smith J M, Ward J M, Sodek J
Science. 1983 Mar 18;219(4590):1329-31. doi: 10.1126/science.6572416.
Transforming growth factors, which are polypeptides that induce the transformed phenotype in nonneoplastic cells, have been isolated in bulk amounts from bovine salivary gland and kidney. In experiments in which wound healing chambers were implanted subcutaneously in the backs of rats, these bovine transforming growth factors accelerated the accumulation of total protein, collagen, and DNA in treated chambers. These studies thus show an effect of an isolated transforming growth factor in vivo.
转化生长因子是一类能在非肿瘤细胞中诱导转化表型的多肽，已从牛唾液腺和肾脏中大量分离出来。在将伤口愈合室皮下植入大鼠背部的实验中，这些牛转化生长因子加速了处理过的室中总蛋白、胶原蛋白和DNA的积累。因此，这些研究显示了一种分离的转化生长因子在体内的作用。
