Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Regul Toxicol Pharmacol. 2017 Nov;90:358-363. doi: 10.1016/j.yrtph.2017.08.022. Epub 2017 Sep 15.
Bisphenol A (BPA) is used in the manufacture of polycarbonate and epoxy resin plastics. There has been interest in the possibility that BPA has immunotoxic properties, and a variety of investigations have explored this. Among the approaches taken have been human observational and cross-sectional studies, investigations using experimental animals, and in vitro studies, some of which have been reviewed previously by the European Food Safety Authority (EFSA). This commentary aims to provide a focused review of data regarding the ability of BPA to perturb the immune system, including the developing immune system, and to cause related adverse health effects. The objective is to complement the evaluations conducted by EFSA, with a focus on the ability of BPA to impair immune function, to promote respiratory allergy and airway inflammation, and to compromise immunological tolerance to dietary proteins. The conclusion drawn is that there is currently no persuasive evidence that BPA has significant immunotoxic potential. This is, in part, due to some of the data reviewed being apparently contradictory or inconsistent, and the investigations from which those data were derived having limitations with regard to experimental design. The conclusion drawn here is that presently there is no clear evidence that BPA has the potential to cause immunotoxicity resulting in adverse health effects.
双酚 A（BPA）用于制造聚碳酸酯和环氧树脂塑料。人们一直关注 BPA 是否具有免疫毒性特性，并且已经进行了各种研究来探索这一特性。所采用的方法包括人体观察性和横断面研究、使用实验动物的研究以及体外研究，其中一些先前已被欧洲食品安全局（EFSA）审查。本评论旨在重点审查关于 BPA 扰乱免疫系统（包括发育中的免疫系统）并导致相关不良健康影响的能力的数据。目的是补充 EFSA 进行的评估，重点关注 BPA 损害免疫功能、促进呼吸道过敏和气道炎症以及损害对膳食蛋白质的免疫耐受的能力。得出的结论是，目前没有令人信服的证据表明 BPA 具有显著的免疫毒性潜力。这部分是由于审查的一些数据显然存在矛盾或不一致，并且这些数据的来源的研究在实验设计方面存在局限性。这里得出的结论是，目前没有明确的证据表明 BPA 具有导致免疫毒性从而产生不良健康影响的潜力。
