De Ocampo Maria P G, Araneta Maria Rosario G, Macera Caroline A, Alcaraz John E, Moore Thomas R, Chambers Christina D
Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA; Division of Epidemiology and Biostatistics, San Diego State University, San Diego, CA, USA.
Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
Women Birth. 2018 Apr;31(2):e77-e83. doi: 10.1016/j.wombi.2017.08.128. Epub 2017 Sep 1.
Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality. Studies suggest that the use of folic acid may lower the risk of hypertensive disorders in pregnant women.
The aim of this study was to assess the effects of timing and duration of folic acid-containing supplement use on the risk for gestational hypertension and preeclampsia.
Exposures and outcomes data were obtained through interviews and review of participant's medical records from the MotherToBaby cohort studies across the United States and Canada. Demographics, medical history, lifestyle factors, substance use, and fetal sex were assessed as potential confounders. Unadjusted and adjusted risks for gestational hypertension and preeclampsia were examined using odds ratios and 95% confidence intervals.
3247 women were included in the study. Compared to non-supplement use, early and late supplement use were not significantly associated with the development of gestational hypertension or preeclampsia. The odds of developing gestational hypertension and preeclampsia were significantly reduced as the duration of folic acid-containing supplement use increased.
Findings from this study suggest that the use of folic acid-containing supplements may mitigate the risk for gestational hypertension and preeclampsia.
妊娠期高血压疾病是孕产妇发病和死亡的主要原因之一。研究表明，使用叶酸可能会降低孕妇患妊娠期高血压疾病的风险。
本研究的目的是评估含叶酸补充剂的使用时间和持续时间对妊娠期高血压和先兆子痫风险的影响。
通过对美国和加拿大母婴队列研究中参与者的访谈和病历审查获取暴露和结局数据。评估人口统计学、病史、生活方式因素、物质使用和胎儿性别作为潜在混杂因素。使用比值比和95%置信区间检查妊娠期高血压和先兆子痫的未调整和调整风险。
3247名女性纳入研究。与不使用补充剂相比，早期和晚期使用补充剂与妊娠期高血压或先兆子痫的发生无显著关联。随着含叶酸补充剂使用时间的增加，发生妊娠期高血压和先兆子痫的几率显著降低。
本研究结果表明，使用含叶酸补充剂可能会降低妊娠期高血压和先兆子痫的风险。
