孕期补充叶酸对妊娠期高血压/子痫前期的影响：一项系统评价与荟萃分析。
Effect of folic acid supplementation during pregnancy on gestational hypertension/preeclampsia: A systematic review and meta-analysis.
作者信息
Hua Xiaolin, Zhang Jiewen, Guo Yanfang, Shen Minxue, Gaudet Laura, Janoudi Ghayath, Walker Mark, Wen Shi Wu
机构信息
a Department of Obstetrics , Xinhua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
b Department of Obstetrics and Gynecology, Faculty of Medicine , OMNI Research Group, University of Ottawa , Ottawa , Ontario , Canada.
出版信息
Hypertens Pregnancy. 2016 Nov;35(4):447-460. doi: 10.1080/10641955.2016.1183673. Epub 2016 Jun 17.
OBJECTIVE
To evaluate the effect of folic acid supplementation during pregnancy on the risk of gestational hypertension/preeclampsia.
METHODS
A systematic review and meta-analysis were conducted. Medline, Embase, Scopus, and the Web of Science were searched from inception to December 2014.
RESULTS
Out of 1224 potentially relevant studies, 13 studies met our inclusion criteria (2 randomized controlled trials (RCTs), 10 cohort studies, and 1 case-control study). The pooled relative risk (RR) and 95% confidence interval (CI) of the two RCTs were 0.62 (0.45-0.87) in the trial arm as compared with the placebo arm. The pooled RR was 0.92 (95% CI: 0.79-1.08) for nine cohort studies with available data on folic acid supplementation in pregnancy and gestational hypertension/preeclampsia. Pooled RR was 0.88 (95% CI: 0.76-1.02) for eight cohort studies with available data on folic acid supplementation and preeclampsia.
CONCLUSION
Whether folic acid supplementation in pregnancy can prevent the occurrence of gestational hypertension/preeclampsia remains uncertain.
目的
评估孕期补充叶酸对妊娠期高血压/子痫前期风险的影响。
方法
进行了一项系统评价和荟萃分析。检索了从数据库建立至2014年12月的Medline、Embase、Scopus和科学引文索引数据库。
结果
在1224项可能相关的研究中，13项研究符合我们的纳入标准（2项随机对照试验、10项队列研究和1项病例对照研究）。与安慰剂组相比，两项随机对照试验中试验组的合并相对风险（RR）和95%置信区间（CI）为0.62（0.45 - 0.87）。对于9项有孕期补充叶酸与妊娠期高血压/子痫前期相关数据的队列研究，合并RR为0.92（95%CI：0.79 - 1.08）。对于8项有叶酸补充与子痫前期相关数据的队列研究，合并RR为0.88（95%CI：0.76 - 1.02）。
结论
孕期补充叶酸是否能预防妊娠期高血压/子痫前期的发生仍不确定。
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