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麻疹病毒突变体对融合抑制性寡肽的抗性与融合肽中的突变无关。

Resistance of a measles virus mutant to fusion inhibitory oligopeptides is not associated with mutations in the fusion peptide.

作者信息

Hull J D, Krah D L, Choppin P W

出版信息

Virology. 1987 Aug;159(2):368-72. doi: 10.1016/0042-6822(87)90475-2.

DOI:10.1016/0042-6822(87)90475-2
PMID:2887065
Abstract

The nucleotide sequence and predicted amino acid sequence has been obtained for the fusion (F) protein gene of the R93 strain of measles virus and compared to that of the parental strain, Edmonston B. The R93 strain is a mutant measles virus which is able to grow and induce cell fusion in the presence of the fusion inhibiting oligopeptide, Z-D-Phe-L-Phe-L-(NO2)Arg (SV4814). Primer extension sequencing on isolated R93 mRNA demonstrated the presence of three nucleotide changes leading to three amino acid changes, none of which are in the hydrophobic NH2-terminal region of the F1 polypeptide.

摘要

已获得麻疹病毒R93株融合(F)蛋白基因的核苷酸序列和预测的氨基酸序列,并与亲代毒株埃德蒙斯顿B株进行了比较。R93株是一种突变麻疹病毒,在融合抑制寡肽Z-D-苯丙氨酸-L-苯丙氨酸-L-(硝基)精氨酸(SV4814)存在的情况下能够生长并诱导细胞融合。对分离的R93 mRNA进行引物延伸测序,结果显示存在三个核苷酸变化,导致三个氨基酸变化,其中没有一个位于F1多肽的疏水氨基末端区域。

相似文献

1
Resistance of a measles virus mutant to fusion inhibitory oligopeptides is not associated with mutations in the fusion peptide.麻疹病毒突变体对融合抑制性寡肽的抗性与融合肽中的突变无关。
Virology. 1987 Aug;159(2):368-72. doi: 10.1016/0042-6822(87)90475-2.
2
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3
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引用本文的文献

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Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors Carbobenzoxy-d-Phe-l-Phe-Gly and 4-Nitro-2-Phenylacetyl Amino-Benzamide.麻疹病毒融合蛋白中赋予对膜融合抑制剂苄氧羰基 - d - 苯丙氨酸 - l - 苯丙氨酸 - 甘氨酸和4 - 硝基 - 2 - 苯基乙酰氨基苯甲酰胺耐药性的突变。
J Virol. 2017 Nov 14;91(23). doi: 10.1128/JVI.01026-17. Print 2017 Dec 1.
2
Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters.具有增强融合活性的突变融合蛋白促进麻疹病毒在人神经细胞和乳仓鼠脑中的传播。
J Virol. 2013 Mar;87(5):2648-59. doi: 10.1128/JVI.02632-12. Epub 2012 Dec 19.
3
Identification of an immunodominant neutralizing and protective epitope from measles virus fusion protein by using human sera from acute infection.
利用急性感染期的人血清鉴定麻疹病毒融合蛋白的一个免疫显性中和及保护性表位。
J Virol. 1997 Oct;71(10):7240-5. doi: 10.1128/JVI.71.10.7240-7245.1997.
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Assignment of disulfide bridges in the fusion glycoprotein of Sendai virus.仙台病毒融合糖蛋白中二硫键的定位
J Virol. 1994 May;68(5):3200-6. doi: 10.1128/JVI.68.5.3200-3206.1994.
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Measles virus fusion: role of the cysteine-rich region of the fusion glycoprotein.麻疹病毒融合:融合糖蛋白富含半胱氨酸区域的作用
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Generation of measles virus defective interfering particles and their presence in a preparation of attenuated live-virus vaccine.麻疹病毒缺陷干扰颗粒的产生及其在减毒活病毒疫苗制剂中的存在。
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