麻疹病毒融合：融合糖蛋白富含半胱氨酸区域的作用
Measles virus fusion: role of the cysteine-rich region of the fusion glycoprotein.
作者信息
Wild T F, Fayolle J, Beauverger P, Buckland R
机构信息
Institut National de la Santé et de la Recherche Médicale U.404, Institut Pasteur de Lyon, France.
出版信息
J Virol. 1994 Nov;68(11):7546-8. doi: 10.1128/JVI.68.11.7546-7548.1994.
Abstract
Measles virus (MV) fusion requires the participation of both the fusion (F) and hemagglutinin (H) glycoproteins. The canine distemper virus fusion protein (CDVF) cannot substitute for the measles virus fusion protein (MVF) in this process. Introduction of restriction enzyme sites into the cDNAs of CDVF and MVF by site-directed mutagenesis facilitated the production of chimeric F proteins which were tested for their capacity to give fusion when coexpressed with MVH. Fusion resulted when the amino-terminal half of the MVF cysteine-rich region was transferred to CDVF.
摘要
麻疹病毒（MV）融合需要融合（F）糖蛋白和血凝素（H）糖蛋白的共同参与。在此过程中，犬瘟热病毒融合蛋白（CDVF）不能替代麻疹病毒融合蛋白（MVF）。通过定点诱变将限制性酶切位点引入CDVF和MVF的cDNA中，有助于产生嵌合F蛋白，这些嵌合F蛋白在与MVH共表达时被测试其融合能力。当MVF富含半胱氨酸区域的氨基末端一半转移到CDVF时，会发生融合。
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