Hamaguchi Reo, Okamoto Toshihiro, Sato Masaaki, Hasegawa Michiko, Wada Hiromi
Karasuma Wada Clinic, Yasaka Karasuma-oike Building 2F, Kyoto, Japan
Transplant Center, Cleveland Clinic, Cleveland, OH, U.S.A.
Anticancer Res. 2017 Sep;37(9):5141-5145. doi: 10.21873/anticanres.11934.
The acidic tumor microenvironment is associated with progression of cancers. The purpose of this study was to investigate the association between an alkaline diet and the effect of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in non-small cell lung cancer (NSCLC) patients.
Eleven advanced or recurrent NSCLC patients with EGFR mutations treated with EGFR-TKI after being instructed to follow an alkaline diet were retrospectively evaluated.
The median progression-free survival (PFS) and overall survival (OS) were 19.5 (range=3.1-33.8) and 28.5 (range=15.4-46.6) months. The average dosage of EGFR-TKI was 56±22% of the standard dosage. Urine pH was significantly increased after the alkaline diet (6.00±0.38 vs. 6.95±0.55; p<0.05).
An alkaline diet may enhance the effect of EGFR-TKI treatment in NSCLC patients with EGFR mutations.
酸性肿瘤微环境与癌症进展相关。本研究旨在探讨碱性饮食与表皮生长因子受体（EGFR）-酪氨酸激酶抑制剂（TKI）对非小细胞肺癌（NSCLC）患者疗效之间的关联。
回顾性评估了11例接受EGFR-TKI治疗的晚期或复发性EGFR突变NSCLC患者，这些患者在接受治疗前被要求遵循碱性饮食。
中位无进展生存期（PFS）和总生存期（OS）分别为19.5个月（范围=3.1-33.8个月）和28.5个月（范围=15.4-46.6个月）。EGFR-TKI的平均剂量为标准剂量的56±22%。碱性饮食后尿pH值显著升高（6.00±0.38对6.95±0.55；p<0.05）。
碱性饮食可能增强EGFR-TKI对EGFR突变NSCLC患者的治疗效果。
