Isowa Masahide, Hamaguchi Reo, Narui Ryoko, Morikawa Hiromasa, Okamoto Toshihiro, Wada Hiromi
Japanese Society on Inflammation and Metabolism in Cancer, 119 Nishioshikouji-cho, Nakagyo-ku, Kyoto 604-0842, Japan.
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
Pharmaceutics. 2024 Jun 10;16(6):787. doi: 10.3390/pharmaceutics16060787.
Cancer treatment is a significant focus in medicine, owing to the increasing global incidence of cancers. Patients with advanced cancers that do not respond to conventional therapies have limited options and an unfavorable prognosis. Consequently, researchers are investigating complementary approaches to conventional treatments. One such approach is alkalization therapy, which aims to neutralize the acidic tumor microenvironment (TME) by increasing its pH level. The acidic TME promotes inflammation, tumor progression, and drug resistance. Alkalization therapy has been demonstrated to be effective for various cancers. In addition, natural products, such as triterpenoids, parthenolides, fulvic acid, , and apple pectin have the potential to alleviate symptoms, maintain physical fitness, and improve treatment outcomes of cancer patients through their anti-inflammatory, antioxidant, and anticancer properties. In this review, we focus on the effects of alkalization therapy and natural products on cancer. Furthermore, we present a case series of advanced cancer patients who received alkalization therapy and natural products alongside standard treatments, resulting in long-term survival. We posit that alkalization therapy together with supplementation with natural products may confer benefits to cancer patients, by mitigating the side effects of chemotherapy and complementing standard treatments. However, further research is warranted to validate these clinical findings.
由于全球癌症发病率不断上升，癌症治疗是医学领域的一个重要焦点。对传统疗法无反应的晚期癌症患者选择有限且预后不佳。因此，研究人员正在探索传统治疗的补充方法。其中一种方法是碱化疗法，其目的是通过提高肿瘤微环境（TME）的pH值来中和酸性肿瘤微环境。酸性肿瘤微环境会促进炎症、肿瘤进展和耐药性。碱化疗法已被证明对各种癌症有效。此外，天然产物，如三萜类化合物、小白菊内酯、富里酸和苹果果胶，具有抗炎、抗氧化和抗癌特性，有可能缓解癌症患者的症状、保持身体健康并改善治疗效果。在本综述中，我们重点关注碱化疗法和天然产物对癌症的影响。此外，我们展示了一系列晚期癌症患者的病例，这些患者在接受标准治疗的同时接受了碱化疗法和天然产物治疗，从而实现了长期生存。我们认为，碱化疗法与天然产物补充剂相结合可能会给癌症患者带来益处，减轻化疗的副作用并补充标准治疗。然而，需要进一步研究来验证这些临床发现。
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