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[分支导管内乳头状黏液性肿瘤——反对切除]

[Branch duct intraductal papillary mucinous neoplasm - contra resection].

作者信息

Brunner M, Weber G F, Kersting S, Grützmann Robert

机构信息

Klink für Allgemein- und Viszeralchirurgie, Universitätsklinikum der Friedrich-Alexander-Universität, Krankenhausstraße 12, 91054, Erlangen, Deutschland.

出版信息

Chirurg. 2017 Nov;88(11):918-926. doi: 10.1007/s00104-017-0495-z.

Abstract

Due to improvements in imaging modalities the diagnosis of branch duct intraductal papillary mucinous neoplasms (BD-IPMN) has been significantly increased in recent years. A BD-IPMN is frequently diagnosed as an incidental finding in asymptomatic patients. The optimal management of BD-IPMN is the subject of controversial discussions. Numerous studies have shown that an individualized therapeutic strategy with a follow-up observation of most BD-IPMNs is feasible and safe, considering age, comorbidities and patient preference. An accurate evaluation of BD-IPMN with a detailed anamnesis, high-resolution imaging techniques and endoscopic ultrasound is necessary. Symptomatic patients as well as patients with so-called high-risk stigmata should undergo resection. Asymptomatic patients with so-called worrisome features can either undergo surveillance or surgical resection, taking age and comorbidities into account. For BD-IPMN patients without high-risk stigmata and worrisome features and showing no symptoms, surveillance of the pancreatic lesion is the preferred approach. The high prevalence of BD-IPMN, limitations in differential diagnostics, an overestimation of the risk of malignancy due to an overrepresentation of symptomatic and suspected BD-IPMN in resected cohorts, an overestimated role of BD-IPMN as precursor lesions for pancreatic carcinoma and evidence of the safety of follow-up surveillance, underline the enormous importance of surveillance. Based on this and considering the background of a notable mortality and morbidity of pancreatic surgery, aggressive management with prophylactic surgical resection is not justified for all BD-IPMN, in particular for low-risk lesions.

摘要

由于成像方式的改进,近年来分支导管内乳头状黏液性肿瘤(BD-IPMN)的诊断率显著提高。BD-IPMN常被诊断为无症状患者的偶然发现。BD-IPMN的最佳管理是一个有争议的讨论话题。大量研究表明,考虑到年龄、合并症和患者偏好,对大多数BD-IPMN进行随访观察的个体化治疗策略是可行且安全的。需要通过详细的病史、高分辨率成像技术和内镜超声对BD-IPMN进行准确评估。有症状的患者以及具有所谓高危特征的患者应接受手术切除。对于具有所谓令人担忧特征的无症状患者,考虑到年龄和合并症,可以进行监测或手术切除。对于没有高危特征和令人担忧特征且无症状的BD-IPMN患者,对胰腺病变进行监测是首选方法。BD-IPMN的高患病率、鉴别诊断的局限性、由于切除队列中有症状和疑似BD-IPMN的比例过高而对恶性风险的高估、BD-IPMN作为胰腺癌前体病变的作用被高估以及随访监测安全性的证据,都强调了监测的巨大重要性。基于此,并考虑到胰腺手术有显著的死亡率和发病率这一背景,对所有BD-IPMN,特别是低风险病变进行积极的预防性手术切除管理是不合理的。

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