Zhao Xinyu, Wang Yan, Zheng Lu, Sun Chengpeng, Wang Chao, Cong Haijian, Xiang Ting, Zhang Lin, Zhang Houli, Deng Sa, Zhang Baojing, Wu Bin, Huo Xiaokui
a College of Pharmacy and College (Institute) of Integrative Medicine , Dalian Medical University , Dalian , PR China.
b Department of Pharmacy and Traditional Chinese Medicine , The 210th Hospital of PLA , Dalian , PR China.
Nat Prod Res. 2018 Sep;32(17):2031-2036. doi: 10.1080/14786419.2017.1365075. Epub 2017 Sep 5.
Shuanghua Baihe tablet is a traditional Chinese patent medicine which showed special advantages in the treatment of recurrent aphthous stomatitis. Scientists have improved and implemented the LC-MS/MS method, which is specific and sensitive, for comparative pharmacokinetics study of five alkaloids, including palmatine, berberine, epiberberine, jatrorrhizine and coptisine in rat plasma after oral administration of Rhizoma Coptidis extract and Shuanghua Baihe tablets. The results showed that Shuanghua Baihe tablets could promote the absorption of these five alkaloids and improved their bioavailability compared with R. Coptidis extract. To further investigate the related mechanism, everted intestinal sac model in vitro was used to indicate that alteration of in vivo pharmacokinetics of five alkaloids could be attributed to, at least in part, the absorption changes by coadministration of other herbs. These discoveries served as a theoretical basis for clinical use of Shuanghua Baihe tables.
双花百合片是一种在复发性口腔溃疡治疗中显示出独特优势的中成药。科学家们改进并实施了LC-MS/MS方法，该方法特异性强且灵敏，用于口服黄连提取物和双花百合片后大鼠血浆中巴马汀、小檗碱、表小檗碱、药根碱和黄连碱这五种生物碱的比较药代动力学研究。结果表明，与黄连提取物相比，双花百合片可促进这五种生物碱的吸收并提高其生物利用度。为进一步研究相关机制，采用体外外翻肠囊模型表明，这五种生物碱体内药代动力学的改变至少部分可归因于与其他草药合用导致的吸收变化。这些发现为双花百合片的临床应用提供了理论依据。
