Omani-Samani Reza, Ranjbaran Mehdi, Amini Payam, Esmailzadeh Arezoo, Sepidarkish Mahdi, Almasi-Hashiani Amir
a Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center , Royan Institute for Reproductive Biomedicine, ACECR , Tehran , Iran.
b Department of Obstetrics and Gynecology , Zahedan University of Medical Sciences , Zahedan , Iran.
J Matern Fetal Neonatal Med. 2019 Jan;32(2):212-216. doi: 10.1080/14767058.2017.1376643. Epub 2017 Sep 18.
Preeclampsia is relatively a common complication in pregnancy and is characterized by high blood pressure and protein in urine during pregnancy. Consistent with the adverse outcomes followed by preeclampsia, this study designed to investigate the how preeclampsia is associated with preterm, low birth weight (LBW), cesarean section, and weigh gain during pregnancy.
In this population-based cross-sectional study, 5166 deliveries from 103 hospitals in Tehran (Capital of Iran) were included in the analysis in 2015. The independent variable was preeclampsia during pregnancy and weight gain during pregnancy, preterm birth, cesarean section, and LBW were considered as interested outcomes. The data were analyzed by statistical Stata software (version 13, Stata Inc., College Station, TX).
Adjusted results showed that the mean of weight gain in women with preeclampsia was significantly higher than women without preeclampsia (mean difference: 1.77 kg, 95%CI: 0.76-12.78, p = .001). The adjusted odds ratio for preterm birth, cesarean section, and LBW were 4.19 (95%CI: 2.71-6.48, p = .001), 1.92 (95%CI: 1.24-2.98, p = .003), and 1.19 (95%CI: 0.61-2.31, p = .599), respectively.
Weight gain in women with preeclampsia was higher than women without preeclampsia and also the odds of preterm birth, cesarean section and LBW in women with preeclampsia was higher than women without preeclampsia.
先兆子痫是孕期相对常见的并发症，其特征为孕期高血压和蛋白尿。与先兆子痫带来的不良后果一致，本研究旨在调查先兆子痫与早产、低出生体重、剖宫产以及孕期体重增加之间的关联。
在这项基于人群的横断面研究中，2015年纳入了来自伊朗首都德黑兰103家医院的5166例分娩病例进行分析。自变量为孕期先兆子痫和孕期体重增加情况，早产、剖宫产和低出生体重被视为感兴趣的结局。数据采用统计软件Stata（版本13，Stata公司，德克萨斯州大学城）进行分析。
校正后的结果显示，先兆子痫女性的体重增加均值显著高于无先兆子痫的女性（均值差异：1.77千克，95%置信区间：0.76 - 12.78，p = 0.001）。早产、剖宫产和低出生体重的校正比值比分别为4.19（95%置信区间：2.71 - 6.48，p = 0.001）、1.92（95%置信区间：1.24 - 2.98，p = 0.003）和1.19（95%置信区间：0.61 - 2.31，p = 0.599）。
先兆子痫女性的体重增加高于无先兆子痫的女性，且先兆子痫女性发生早产、剖宫产和低出生体重的几率也高于无先兆子痫的女性。
