Maghsudlu Salome, Ghazanfari Hashemi Mohamad, Talebi Vahid, Vahabi Elham, Sharifpour Sanaz, Hajibeygi Ramtin, Maleki Farajolah
Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Radiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Int J Fertil Steril. 2023 Aug 7;17(4):231-235. doi: 10.22074/ijfs.2023.559787.1349.
Human leukocyte antigen G (HLA-G) levels are among the biomarkers suggested for pre-eclampsia (PE). This study is aimed at determining the possible relationship between low soluble HLA-G (sHLA-G) levels in maternal blood at the beginning of pregnancy and subsequent PE. We searched the international scientific databases of Web of Science, Embase, PubMed, Cochrane, and Scopus. We extracted the studies investigating the relationship between the serum levels of HLA-G in the first trimester of pregnancy and the onset of PE using the appropriate keywords. The collected data were analyzed using the random-effects meta-analysis model and STATA (version 14). A total of 5 studies met the eligibility criteria, and the total sample size was 668 subjects. The mean and SD age of case subjects was 31.41 ± 4.16 years, while it was 30.56 ± 3.5 for control subjects. According to the findings, there was an inverse relationship between HLA-G serum level in the first trimester of pregnancy and the subsequent onset of PE, standard mean difference (SMD)=-1.51 [95% confidence interval (CI): -2.26, -0.75, I2=90.8%, P=0.000]. Based on these results, low sHLA-G level in early pregnancy has a positive correlation with subsequent PE, and the significant role of sHLA-G in the early stages of placentation can be proven.
人类白细胞抗原G（HLA-G）水平是子痫前期（PE）所建议的生物标志物之一。本研究旨在确定妊娠初期母血中低可溶性HLA-G（sHLA-G）水平与随后发生的PE之间的可能关系。我们检索了科学网、Embase、PubMed、Cochrane和Scopus等国际科学数据库。我们使用适当的关键词提取了调查妊娠早期血清HLA-G水平与PE发病之间关系的研究。使用随机效应荟萃分析模型和STATA（版本14）对收集的数据进行分析。共有5项研究符合纳入标准，总样本量为668名受试者。病例组受试者的平均年龄和标准差为31.41±4.16岁，而对照组为30.56±3.5岁。根据研究结果，妊娠早期HLA-G血清水平与随后发生的PE之间存在负相关，标准平均差（SMD）=-1.51 [95%置信区间（CI）：-2.26，-0.75，I2=90.8%，P=0.000]。基于这些结果，妊娠早期低sHLA-G水平与随后发生的PE呈正相关，并且可以证明sHLA-G在胎盘形成早期阶段具有重要作用。
