Department of Public Health, Graduate School, Dankook University, Cheonan, Republic of Korea.
Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea.
J Periodontol. 2018 Jan;89(1):28-35. doi: 10.1902/jop.2017.170111.
Hyperlipidemia is a known risk factor for cardiovascular diseases. A common biologic mechanism between systemic diseases, such as cardiovascular diseases, and periodontal diseases has been suggested. The aim of this study is to examine the association between blood lipid profile and periodontitis.
The study included 6,905 Korean adults, aged ≥ 20 years. Individuals with incomplete data on blood lipid levels, those who lacked results of periodontitis examination using the Community Periodontal Index system in the Fifth Korean National Health and Nutrition Examination Survey for 2010 and 2012 and those diagnosed with diabetes mellitus, hypertension, and hyperlipidemia were excluded from the study. All analyses involved complex sampling design. The association was assessed using multiple logistic regression analysis adjusted for covariates.
Women with low high-density lipoprotein (HDL) cholesterol levels showed a significantly higher risk of periodontitis (odds ratio (OR) [95% confidence interval (CI)]: 1.65 [1.03 to 2.66] for the lowest group) than those with high HDL levels. Women with high low-density lipoprotein (LDL) cholesterol levels showed a higher risk of the disease (OR [95% CI]: 2.38 [1.01 to 5.60] for the highest group) than those with low LDL levels. There were significant dose-response relationships between disease risk and levels of HDL and LDL (P trend of 0.001 and 0.04, respectively). There was no significant difference in the risk between pre- and postmenopausal women. Men did not show any significant association between blood lipid levels and periodontitis.
There was a significant association between periodontitis and low HDL and high LDL cholesterol levels in women. J Periodontol 2018;89:000-000.
高血脂是心血管疾病的已知危险因素。有人提出，系统性疾病（如心血管疾病和牙周病）之间存在共同的生物学机制。本研究旨在探讨血脂谱与牙周炎之间的关系。
该研究纳入了 6905 名年龄≥20 岁的韩国成年人。在韩国 2010 年和 2012 年第五次全国健康和营养调查中，对那些血脂水平数据不完整、缺乏使用社区牙周指数系统检查牙周炎结果、患有糖尿病、高血压和高血脂的个体进行了排除。所有分析均涉及复杂抽样设计。采用多因素 logistic 回归分析调整了协变量。
女性中，低高密度脂蛋白（HDL）胆固醇水平者患牙周炎的风险显著升高（比值比[OR] [95%置信区间[CI]]：最低组 1.65 [1.03 至 2.66]）。女性中，高低密度脂蛋白（LDL）胆固醇水平者患牙周炎的风险较高（最高组 OR [95% CI]：2.38 [1.01 至 5.60]）。HDL 和 LDL 水平与疾病风险之间存在显著的剂量-反应关系（P 趋势分别为 0.001 和 0.04）。绝经前和绝经后女性的风险无显著差异。男性的血脂水平与牙周炎之间无显著相关性。
女性牙周炎与低 HDL 和高 LDL 胆固醇水平显著相关。牙周病学 2018；89：000-000。
