Mediation roles of neutrophils and high-density lipoprotein (HDL) on the relationship between HLA-DQB1 and rosacea.

BACKGROUND

Though the previous genome-wide association studies found the association between alleles and rosacea in the European populations, the data is lacking among the Asians. Moreover, neutrophils are important in the immune-related mechanism of rosacea, and dyslipidemia is closely related to rosacea. We aimed to explore the association between genes and rosacea in Chinese rosacea patients, as well as the mediation effect of neutrophils, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) on the relationship between genes and rosacea.

METHODS

A total of 249 rosacea and 150 controls were ranked by the international investigator global rosacea severity scores. genes, neutrophils, HDL, and LDL were detected. And their mediation effects on the relationship between and rosacea risk or severity were analysed.

RESULTS

allele (OR = 41.89, 95% CI: 9.80 ∼ 179.09,  = 4.710), allele (OR = 0.16, 95% CI: 0.03 ∼ 0.81,  = 0.026) and genotype (OR = 5.57, 95% CI: 1.13 ∼ 27.52,  = 0.0351) were significantly associated with rosacea. Moreover, allele (b = 1.434, SE = 0.217,  = 2.010), allele (b = 0.894, SE = 0.33520,  = 0.008) and genotype (b = 0.998, SE = 0.472,  = 0.040) were positively associated with rosacea severity. Furthermore, we found both neutrophils and HDL, instead of LDL, have mediation effects on the relationship between and risk or severity of rosacea.

CONCLUSIONS

We discovered novel susceptible alleles for rosacea in the Chinese population, and disclosed the mediation effect of neutrophils and HDL on the relationship between and rosacea, implying a possible correlation between rosacea and inflammatory or metabolic factors, providing hints for future studies in the mechanism of rosacea. Key messages allele, allele and genotype were significantly associated with rosacea. allele, allele and genotype were positively associated with rosacea severity.Neutrophils and HDL have mediation effects on the relationship between and risk or severity of rosacea.