From the Hamamatsu/Queen's PET Imaging Center, The Queen's Medical Center, Honolulu, HI.
Clin Nucl Med. 2017 Nov;42(11):868-871. doi: 10.1097/RLU.0000000000001807.
Two patients with castrate-resistant prostate cancer and symptomatic skeletal metastases underwent F-fluorocholine PET/CT prior to treatment with Ra-dichloride to reveal additional active lesions in the prostate gland and lymph nodes. Subsequent scans performed at the midpoint and end of Ra-dichloride therapy showed resolution of this soft tissue activity alongside declining bone lesion activity. Concomitant increases in plasma interleukin 6 were detected, suggesting that immune system activation may have mediated the soft tissue response. Abscopal effects usually encountered with external beam radiotherapy may also be occurring with Ra-dichloride therapy.
两名去势抵抗性前列腺癌且有症状性骨骼转移的患者，在接受镭-223 二氯化物治疗前进行了 F-氟代胆碱 PET/CT，以显示前列腺和淋巴结中额外的活性病变。镭-223 二氯化物治疗中期和结束时进行的后续扫描显示，这些软组织活性以及骨病变活性下降得到了缓解。同时检测到血浆白细胞介素 6 升高，表明免疫系统激活可能介导了软组织反应。镭-223 二氯化物治疗时可能也会出现与外照射放疗通常遇到的远隔效应。
