Zeisberger E
Can J Physiol Pharmacol. 1987 Jun;65(6):1395-401. doi: 10.1139/y87-219.
Recent studies of the organization of the thermoregulatory system and evaluation of experimental evidence from electrophysiological, neuropharmacological, and neuroanatomical studies suggest that the monoamines noradrenaline and 5-hydroxytryptamine are involved in modulations of thermoregulation rather than in thermoregulation per se: they do not seem to transfer specific thermal information but rather modulate the signals passing from thermosensors to thermoregulatory effectors. Theoretically, the central monoamines could be modulating the input from thermosensors, or the central integration of thermal signals, or the outflow of signals to thermoregulatory effectors. The modulatory action of the monoamines on thermosensitive and thermointegrative hypothalamic neurons is best documented. There, the monoamines 5-hydroxytryptamine and noradrenaline seem to act as antagonists, which enhance or diminish the effects of thermal afferents mediated by other transmitters. Moreover, the antagonistic monoaminergic systems are apparently interconnected and can influence each other at a lower brain stem level. The activity in central monoaminergic systems can also be modified by neurohumoral feedback mechanisms from the periphery. By means of these interrelations the vegetative responses of the organism can be corrected and optimized.
最近对体温调节系统组织的研究以及对来自电生理、神经药理学和神经解剖学研究的实验证据的评估表明，单胺类物质去甲肾上腺素和5-羟色胺参与体温调节的调制，而非体温调节本身：它们似乎并不传递特定的热信息，而是调制从热传感器传递到体温调节效应器的信号。从理论上讲，中枢单胺类物质可能在调制来自热传感器的输入，或热信号的中枢整合，或信号向体温调节效应器的输出。单胺类物质对下丘脑热敏和热整合神经元的调制作用有充分的文献记载。在那里，单胺类物质5-羟色胺和去甲肾上腺素似乎起拮抗剂的作用，增强或减弱由其他递质介导的热传入的效应。此外，拮抗单胺能系统显然相互连接，并且在较低的脑干水平上可以相互影响。中枢单胺能系统的活动也可以通过来自外周的神经体液反馈机制来改变。通过这些相互关系，生物体的自主反应可以得到校正和优化。
