可见光触发的羰基硫解笼以释放硫化氢 (HS)。
Visible-Light-Triggered Uncaging of Carbonyl Sulfide for Hydrogen Sulfide (HS) Release.
机构信息
Department of Chemistry, Indian Institute of Science Education and Research Pune , Dr. Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra, India.
Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science , Bangalore, Karnataka, India.
出版信息
Org Lett. 2017 Sep 15;19(18):4822-4825. doi: 10.1021/acs.orglett.7b02259. Epub 2017 Sep 5.
Generation of hydrogen sulfide (HS) is challenging and few methods are capable of localized delivery of this gas. Here, a boron dipyrromethene-based carbamothioate (BDP-HS) that is uncaged by visible light of 470 nm to generate carbonyl sulfide (COS), which is rapidly hydrolyzed to HS in the presence of carbonic anhydrase, a widely prevalent enzyme, is reported.
生成硫化氢（HS）具有挑战性，很少有方法能够实现这种气体的局部输送。在这里，报道了一种基于硼二吡咯甲川的碳酰胺硫代（BDP-HS），它可以在 470nm 的可见光下解笼以生成碳酰硫（COS），在碳酸酐酶（一种广泛存在的酶）存在下，COS 迅速水解生成 HS。
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