近红外光可见的硫化氢光活化用于生物靶向。
Visible to NIR Light Photoactivation of Hydrogen Sulfide for Biological Targeting.
机构信息
Department of Chemistry and RECETOX, Faculty of Science , Masaryk University , Kamenice 5 , 625 00 , Brno , Czech Republic.
Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine , Charles University , Na Bojišti 3 , 121 08 Praha 2 , Czech Republic.
出版信息
Org Lett. 2018 Aug 17;20(16):4907-4911. doi: 10.1021/acs.orglett.8b02043. Epub 2018 Jul 31.
The synthesis and photochemical properties of HS-releasing BODIPY thiocarbamate photocage scaffolds activatable by visible-to-NIR (up to 700 nm) light to release carbonyl sulfide (COS), which is transformed to HS using either isolated or natural carbonic anhydrase, is reported. The excellent uncaging cross section and high HS release yields in in vitro experiments, including live-cell imaging, suggest that these photocages can serve as a platform for the bio-orthogonal phototriggered release within the tissue-transparent window.
报道了一种通过可见光至近红外（高达 700nm）光激活的 HS 释放 BODIPY 硫代氨基甲酸酯光笼支架的合成和光化学性质，该支架可以释放羰基硫（COS），然后使用分离的或天然碳酸酐酶将其转化为 HS。在体外实验中，包括活细胞成像，这些光笼表现出优异的无笼化截面和高 HS 释放产率，这表明它们可以作为组织透明窗内生物正交光触发释放的平台。
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