细胞衰老在出生时间中的作用。
A role for cellular senescence in birth timing.
机构信息
a Division of Diabetes, Endocrinology and Metabolism , Vanderbilt University Medical Center , Nashville , TN , USA.
b Department of Medicine , Vanderbilt University Medical Center , Nashville , TN , USA.
出版信息
Cell Cycle. 2017;16(21):2023-2031. doi: 10.1080/15384101.2017.1371888. Epub 2017 Sep 25.
Abstract
Senescence contributes to the local and systemic aging of tissues and has been associated with age-related diseases. Recently, roles for this process during pregnancy have come to light, the dysregulation of which has been associated with adverse pregnancy outcomes such as preterm birth. Here, we summarize recent advances that support a role for senescence in birth timing and propose new aspects of study in this emerging field.
摘要
衰老导致组织的局部和全身衰老，并与与年龄相关的疾病有关。最近，人们发现这个过程在怀孕期间也有作用，其失调与早产等不良妊娠结局有关。在这里，我们总结了支持衰老在分娩时间中起作用的最新进展，并提出了这一新兴领域的新研究方向。
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