Centre of Human & Aerospace Physiological Sciences & Centre for Stem Cells and Regenerative Medicine, Faculty of Life Sciences & Medicine, King's College London, London, SE1 1UL, United Kingdom.
Centre of Human & Aerospace Physiological Sciences & Centre for Stem Cells and Regenerative Medicine, Faculty of Life Sciences & Medicine, King's College London, London, SE1 1UL, United Kingdom.
Pharmacol Res. 2018 Jan;127:33-40. doi: 10.1016/j.phrs.2017.08.016. Epub 2017 Sep 2.
The adult myocardium, including human, harbours a population of resident multi-potent cardiac stem cells (CSCs), which when stimulated under the right conditions can give rise to new cardiomyocytes and vasculature. Elucidation of the cellular and molecular mechanisms that govern CSC biology and their role in myocardial regeneration will allow the design and development of optimal therapeutic interventions. It is now evident that different growth factors and cytokines govern CSC survival, proliferation, migration and differentiation, as well as playing a role in activating cardiac repair mechanisms such as improving angiogenesis, cardiomyocyte survival and limiting fibrosis. This review article will summarize the evidence for a role of VEGF, NRG-1, IGF-1, HGF, EGF, FGF and TGF-β1 in modulating the repair and regeneration of cardiac tissue. It will also discuss the use of exosomes and exercise training as interventions to stimulate the endogenous repair and regenerative mechanisms in the damaged heart.
成人心肌（包括人类）中存在一群常驻多能心脏干细胞（CSC），在适当条件下刺激这些细胞可以产生新的心肌细胞和血管。阐明调控 CSC 生物学及其在心肌再生中作用的细胞和分子机制，将有助于设计和开发最佳的治疗干预措施。目前已经明确，不同的生长因子和细胞因子调控 CSC 的存活、增殖、迁移和分化，同时也在激活心脏修复机制中发挥作用，如促进血管生成、心肌细胞存活和减少纤维化。本文综述了 VEGF、NRG-1、IGF-1、HGF、EGF、FGF 和 TGF-β1 在调节心脏组织修复和再生中的作用，还讨论了外泌体和运动训练作为刺激受损心脏内源性修复和再生机制的干预措施的应用。
