未结合胆红素对肾组织毒性作用的可能机制。
Possible mechanism of unconjugated bilirubin toxicity on renal tissue.
作者信息
Elías M M, Comin E J, Grosman M E, Galeazzi S A, Rodríguez Garay E A
出版信息
Comp Biochem Physiol A Comp Physiol. 1987;87(4):1003-7. doi: 10.1016/0300-9629(87)90027-2.
PMID:2887366
Abstract
- The effects of unconjugated bilirubin on rat renal tissue metabolism and organic anion transport were investigated using cortical slices. 2. Unconjugated bilirubin in the medium decreased slice-to-medium ratio of p-aminohippurate, altered intracellular Na+ and K+, and decreased ATP content without modifications of (Na+-K+) ATPase. 3. The effects were similar to those of ethacrynic acid and cyanide but less marked. 4. The presence of probenecid blocked the effect of pigment on intracellular electrolytes. 5. The results suggest that pigment is taken up by renal tissue using the organic anion transport system, and within the cell inhibits ATP production.
摘要
- 使用肾皮质切片研究了未结合胆红素对大鼠肾组织代谢和有机阴离子转运的影响。2. 培养基中的未结合胆红素降低了对氨基马尿酸的切片与培养基比值，改变了细胞内的钠和钾含量，降低了ATP含量，而（钠 - 钾）ATP酶没有改变。3. 这些作用与依他尼酸和氰化物的作用相似，但不太明显。4. 丙磺舒的存在阻断了色素对细胞内电解质的作用。5. 结果表明，色素通过有机阴离子转运系统被肾组织摄取，并在细胞内抑制ATP生成。
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