胆红素光衍生物的肾脏处理。

Renal handling of bilirubin photoderivatives.

作者信息

Elías M M, Comin E J, Ochoa J E, Rodríguez Garay E A

出版信息

Experientia. 1987 Aug 15;43(8):875-8. doi: 10.1007/BF01951646.

DOI:10.1007/BF01951646

Abstract

The renal handling of unconjugated bilirubin in the dark and during light exposure was analyzed using an isolated rat kidney preparation. The parameters tested were pigment disappearance from the perfusion medium, pigment uptake by tissue, and its renal clearance. The results indicated that despite the fact that pigment disappearance from the medium was similar for both forms of pigment, the extraction ratio was higher for irradiated pigment than for pigment in the dark. When renal clearance of pigment was plotted vs pigment uptake of tissue, the results indicated that irradiated pigment may be more efficiently removed by the kidney. In addition, data on the rate of secretion of p-aminohippurate suggested that both pigment forms shared a common site for secretion.

摘要

使用离体大鼠肾脏制备物分析了未结合胆红素在黑暗中和光照期间的肾脏处理情况。所测试的参数包括灌注介质中色素的消失、组织对色素的摄取及其肾脏清除率。结果表明，尽管两种形式的色素从介质中消失的情况相似，但照射后的色素提取率高于黑暗中的色素。当绘制色素的肾脏清除率与组织对色素的摄取关系图时，结果表明照射后的色素可能被肾脏更有效地清除。此外，对对氨基马尿酸分泌速率的数据表明，两种色素形式共享一个共同的分泌位点。