Applied Neuromechanics Group, Laboratory of Neuromechanics, Universidade Federal do Pampa, Uruguaiana, RS, Brazil.
Physiology Research Group, Stress, Memory and Behavior Lab, Universidade Federal do Pampa, Uruguaiana, RS, Brazil.
Food Res Int. 2017 Oct;100(Pt 1):442-448. doi: 10.1016/j.foodres.2017.07.026. Epub 2017 Jul 14.
Green tea from Camellia sinensis plays a neuroprotective role in different neurodegenerative conditions, such as memory deficits in Alzheimer disease (AD). However, whether other teas from Camellia sinensis present similar neuroprotective effect still is not clear. Here we investigate effects of green, red and black tea supplementation on memory and hippocampus oxidative status in a rat model of Alzheimer-like disease (AD-like).
Wistar male rats were supplemented with green, red or black tea during 8weeks before Aβ intra-hippocampal injection (2μL of Aβ-25-35, CA1 region). AD and sham rats were submitted to memory tests. After euthanasia, oxidative status in the bilateral hippocampus was quantified. Green and red teas avoid memory deficits in AD rats, but only green tea also avoids oxidative stress and damage in the hippocampus. Green tea was more effective for neuroprotection than red and black teas from the Camellia sinensis in the AD rat model.
来自山茶属的绿茶在不同的神经退行性疾病中发挥神经保护作用，如阿尔茨海默病（AD）中的记忆缺陷。然而，来自山茶属的其他茶是否具有类似的神经保护作用尚不清楚。在这里，我们研究了绿茶、红茶和黑茶补充剂对阿尔茨海默病样疾病（AD 样）大鼠模型中记忆和海马氧化状态的影响。
在 Aβ 海马内注射（CA1 区 2μL Aβ-25-35）前 8 周，用绿茶、红茶或黑茶补充 Wistar 雄性大鼠。AD 和假手术大鼠进行记忆测试。安乐死后，定量测定双侧海马的氧化状态。绿茶和红茶可避免 AD 大鼠的记忆缺陷，但只有绿茶还可避免海马中的氧化应激和损伤。在 AD 大鼠模型中，绿茶对神经保护的效果优于来自山茶属的红茶和黑茶。
