Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of Pampa, Uruguaiana, RS, Brazil.
Multicentric Graduate Program in Physiological Sciences, Federal University of Pampa, Uruguaiana, RS, Brazil.
Neural Plast. 2018 Aug 2;2018:5158724. doi: 10.1155/2018/5158724. eCollection 2018.
Green tea from plays a well-established neuroprotective role in several neurodegenerative diseases, including intracerebral hemorrhage (ICH). However, the other teas of the same plant do not have their properties well understood; but they can be as effective as green tea as an alternative therapy. In this study, we investigated the effects of supplementation with green tea and red tea from on motor deficits and striatum oxidative damage in rats submitted to hemorrhagic stroke (ICH). Male Wistar rats were supplemented with green tea, red tea, or vehicle for 10 days prior to ICH induction. After injury, the rats were submitted to motor tests (open field for locomotion, rotarod for balance, and neurological deficit scale (NDS)) 1, 3, and 7 days after ICH induction, while the tea supplementation was maintained. Subsequently, the rats were euthanized to striatal tissue dissection for biochemical analyzes (lipid peroxidation, reactive oxygen species, glutathione levels, and total antioxidant capacity). ICH caused locomotor and balance deficits, as well as increased the neurological deficit (NDS). Only red tea prevented locomotor deficits after injury. Green tea and red tea prevented balance deficits on the seventh day after ICH. On NDS evaluation, green tea presented a better neuroprotection than red tea (until day 3 after ICH injury). In addition, ICH increased reactive oxygen species and lipid peroxidation levels, without altering antioxidant markers. Green and red teas were effective in decreasing the lipid peroxidation levels. Therefore, green and red teas partially prevented the motor deficits and striatal oxidative damage induced by ICH. Based on our results, we can consider that the two teas seem to be equally effective to prevent motor deficits and striatal oxidative damage induced by hemorrhagic stroke in rats.
来自 的绿茶在几种神经退行性疾病中发挥了明确的神经保护作用，包括脑出血（ICH）。然而，该植物的其他茶类的特性尚未得到很好的理解；但它们可以像绿茶一样作为替代疗法一样有效。在这项研究中，我们研究了补充绿茶和红茶对脑出血（ICH）大鼠运动缺陷和纹状体氧化损伤的影响。雄性 Wistar 大鼠在 ICH 诱导前 10 天补充绿茶、红茶或载体。损伤后，大鼠在 ICH 诱导后 1、3 和 7 天进行运动测试（旷场运动、转棒平衡和神经缺陷评分（NDS）），同时维持茶补充。随后，大鼠被安乐死以进行纹状体组织解剖进行生化分析（脂质过氧化、活性氧、谷胱甘肽水平和总抗氧化能力）。ICH 导致运动和平衡缺陷，并增加神经缺陷（NDS）。只有红茶在受伤后防止了运动缺陷。绿茶和红茶在 ICH 后第 7 天防止了平衡缺陷。在 NDS 评估中，绿茶的神经保护作用优于红茶（ICH 损伤后第 3 天）。此外，ICH 增加了活性氧和脂质过氧化水平，而没有改变抗氧化标志物。绿茶和红茶可有效降低脂质过氧化水平。因此，绿茶和红茶部分预防了 ICH 引起的运动缺陷和纹状体氧化损伤。基于我们的结果，我们可以认为这两种茶似乎对预防大鼠脑出血引起的运动缺陷和纹状体氧化损伤同样有效。
