Zhang Jing-Zhan, Zheng Ying-Ying, Yang Yi-Ning, Li Xiao-Mei, Fu Zhen-Yan, Dai Chuan-Fang, Liu Fen, Chen Bang-Dang, Gai Min-Tao, Ma Yi-Tong, Xie Xiang
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China.
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China
J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):827-37. doi: 10.1177/1470320315615047. Epub 2015 Nov 3.
Polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with coronary heart disease (CHD). However, the results on this topic are conflicting. The present study aims to derive a more precise estimation of the relationship between CHD and apoB genetic polymorphisms by meta-analysis.
We identified a total of 54 studies involving 7236, 10,912, and 14,102 individuals, respectively, for EcoRI, XbaI, and SpIns/Del polymorphisms by searching in PubMed, Web of Science, Google Scholar, the Cochrane Library, Wanfang Data, SinoMed, and CNKI. We utilized RevMan 5.0 software to perform the meta-analyses.
A significant statistical association between apoB EcoRI polymorphism and CHD was observed under an allelic (p = 0.001, odds ratio (OR) = 1.33, 95% confidence interval (CI) = 1.12-1.57), dominant (p = 0.005, OR = 1.22, 95% CI = 1.06-1.40), and recessive (p = 0.04, OR = 1.33, 95% CI = 1.01-1.74) model. We also found similar association of apoB SpIns/Del polymorphism with CHD. However, we did not find association between apoB XbaI polymorphism and CHD.
The current meta-analysis found an association of EcoRI polymorphism and SpIns/Del polymorphism with an increased risk of CHD. No significant association between apoB XbaI polymorphism and CHD we observed in the present study.
已有报道称载脂蛋白B（apoB）基因多态性与冠心病（CHD）相关。然而，关于这一话题的研究结果相互矛盾。本研究旨在通过荟萃分析更精确地评估冠心病与apoB基因多态性之间的关系。
我们通过检索PubMed、科学网、谷歌学术、考克兰图书馆、万方数据、中国生物医学文献数据库和中国知网，分别确定了54项研究，涉及EcoRI、XbaI和SpIns/Del多态性的个体分别为7236、10912和14102人。我们使用RevMan 5.0软件进行荟萃分析。
在等位基因（p = 0.001，比值比（OR）= 1.33，95%置信区间（CI）= 1.12 - 1.57）、显性（p = 0.005，OR = 1.22，95% CI = 1.06 - 1.40）和隐性（p = 0.04，OR = 1.33，95% CI = 1.01 - 1.74）模型下，观察到apoB EcoRI多态性与冠心病之间存在显著的统计学关联。我们还发现apoB SpIns/Del多态性与冠心病有类似关联。然而，我们未发现apoB XbaI多态性与冠心病之间存在关联。
当前的荟萃分析发现EcoRI多态性和SpIns/Del多态性与冠心病风险增加有关。在本研究中，我们未观察到apoB XbaI多态性与冠心病之间存在显著关联。
